Clemizole hydrochloride, a potent TRPC5 calcium channel inhibitor, prevents cisplatin-induced nephrotoxicity in Spraque-Dawley rats.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of biochemical and molecular toxicology"
DOI: 10.1002/jbt.23372
Abstract: Cis-diamminedichloroplatinum (II) (cisplatin, Cis) is widely employed to treat several types of cancer. It has many important toxic side effects; one of the most important of which is nephrotoxicity. Clemizole hydrochloride (Clem) as the most… read more here.
Keywords: clem; clemizole hydrochloride; doses clem; cis ... See more keywords
HPM live μ for a full CLEM workflow.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in cell biology"
DOI: 10.1016/bs.mcb.2020.10.022
Abstract: With the development of advanced imaging methods that took place in the last decade, the spatial correlation of microscopic and spectroscopic information-known as multimodal imaging or correlative microscopy (CM)-has become a broadly applied technique to… read more here.
Keywords: fixation; clem; microscopy; hpm ... See more keywords