Phytotoxic neo-clerodane diterpenoids from the aerial parts of Scutellaria barbata.
Sign Up to like & getrecommendations! Published in 2020 at "Phytochemistry"
DOI: 10.1016/j.phytochem.2019.112230
Abstract: Bioactivity guided the isolation of extracts from the aerial parts Scutellaria barbata D. Don to discover neo-clerodane diterpenoids with potent phytotoxic activity. Of the 34 isolates, 13 neo-clerodane diterpenoids were described for the first time.… read more here.
Keywords: clerodane diterpenoids; neo clerodane; parts scutellaria; aerial parts ... See more keywords
Clerodane diterpenoids from Dodonaea viscosa and their inhibitory effects on ATP citrate lyase.
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DOI: 10.1016/j.phytochem.2020.112614
Abstract: Six undescribed clerodane diterpenoids, dodovisins A-F, together with nine known ones, were isolated from the aerial parts of Dodonaea viscosa (L.) Jacq. Their structures were elucidated by extensive spectroscopic techniques, X-ray crystallographic analysis, and ECD… read more here.
Keywords: citrate lyase; atp citrate; clerodane; clerodane diterpenoids ... See more keywords
Antifeedant, cytotoxic, and anti-inflammatory neo-clerodane diterpenoids in the peltate glandular trichomes and fresh leaves of Ajuga forrestii.
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DOI: 10.1016/j.phytochem.2021.112731
Abstract: The Lamiaceae plant Ajuga forrestii Diels is a traditional Chinese herbal medicine with abundant glandular trichomes (GTs), but their chemistry and biological functions remain uninvestigated. Here, a panel of six highly functionalized neo-clerodane diterpenoids was… read more here.
Keywords: medicine; clerodane diterpenoids; neo clerodane; glandular trichomes ... See more keywords
Neo-clerodane diterpenoids from Teucrium polium subsp. vincentinum (rouy) D. Wood
Sign Up to like & getrecommendations! Published in 2019 at "Phytochemistry Letters"
DOI: 10.1016/j.phytol.2019.04.013
Abstract: Abstract Four neo-clerodane diterpenoids, the new polivincins A – C and the known teulamifin B, were isolated by the phytochemical investigation of the acetone extract prepared from the aerial parts of Teucrium polium subsp. vincentinum,… read more here.
Keywords: neo clerodane; subsp vincentinum; polium subsp; clerodane diterpenoids ... See more keywords
Neo-clerodane diterpenoids from Scutellaria barbata and their reversal multidrug resistance activity in HepG2/Adr cells
Sign Up to like & getrecommendations! Published in 2020 at "Phytochemistry Letters"
DOI: 10.1016/j.phytol.2019.11.014
Abstract: Abstract Bioassay-guided isolation of the aerial part of Scutellaria barbata (Labiatae) yielded six new neo-clerodane diterpenoids scutegxbatines A–F (1-6), together with thirteen known analogues (7-20). Their structures were elucidated on the basis of extensive spectroscopic… read more here.
Keywords: clerodane diterpenoids; hepg2 adr; neo clerodane; adr cells ... See more keywords
Clerodane Diterpenoids Isolated from the Leaves of Casearia graveolens.
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DOI: 10.1021/acs.jnatprod.9b00515
Abstract: A phytochemical survey aiming to acquire pharmacologically active substances has resulted in the isolation of nine new clerodane diterpenoids, named graveospenes A-I (1-9), from the leaves of Casearia graveolens. Spectroscopic methods were employed to establish… read more here.
Keywords: isolated leaves; clerodane diterpenoids; leaves casearia; casearia graveolens ... See more keywords
Four Clerodane Diterpenoids From Ptychopetalum Olacoides
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DOI: 10.1177/1934578x221108534
Abstract: A phytochemical component investigation of the bark of Ptychopetalum olacoides led to the isolation of 4 new clerodane-type diterpenoids, namely, ptycholide V (1), 7α,20-dihydroxykolavelool (2), ptycholide VI (3), and ptycholide VII (4). Their structures were… read more here.
Keywords: clerodane; clerodane diterpenoids; diterpenoids ptychopetalum; ptychopetalum olacoides ... See more keywords
The drug likeness analysis of anti-inflammatory clerodane diterpenoids
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DOI: 10.1186/s13020-020-00407-w
Abstract: Inflammation is an active defense response of the body against external stimuli. Long term low-grade inflammation has been considered as a deteriorated factor for aging, cancer, neurodegeneration and metabolic disorders. The clinically used glucocorticoids and… read more here.
Keywords: anti inflammatory; clerodane diterpenoids; inflammation; drug likeness ... See more keywords
Clerodane Diterpenoids from an Edible Plant Justicia insularis: Discovery, Cytotoxicity, and Apoptosis Induction in Human Ovarian Cancer Cells
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DOI: 10.3390/molecules26195933
Abstract: Objectives: The toxicity of chemotherapeutic anticancer drugs is a serious issue in clinics. Drug discovery from edible and medicinal plants represents a promising approach towards finding safer anticancer therapeutics. Justicia insularis T. Anderson (Acanthaceae) is… read more here.
Keywords: clerodane diterpenoids; plant; apoptosis; ovarian cancer ... See more keywords