The chloride intracellular channel protein CLIC4 inhibits filopodium formation induced by constitutively active mutants of formin mDia2
Sign Up to like & getrecommendations! Published in 2020 at "FEBS Letters"
DOI: 10.1002/1873-3468.13766
Abstract: Chloride intracellular channel 4 (CLIC4) functions in diverse actin‐dependent processes. Upon Rho activation, CLIC4 reversibly translocates from the cytosol to the plasma membrane to regulate cell adhesion and migration. At the plasma membrane, CLIC4 counters… read more here.
Keywords: chloride intracellular; mdia2; constitutively active; intracellular channel ... See more keywords
CLIC4 abrogation promotes epithelial mesenchymal transition in gastric cancer.
Sign Up to like & getrecommendations! Published in 2019 at "Carcinogenesis"
DOI: 10.1093/carcin/bgz156
Abstract: CLIC4 has been implicated in different types of cancers, but the role of CLIC4 in the development of gastric cancer (GC) remains unknown. We analyzed the expression of CLIC4 in 102 pairs of gastric adenocarcinomas… read more here.
Keywords: mesenchymal transition; gastric cancer; epithelial mesenchymal; expression ... See more keywords
CLIC4 localizes to mitochondrial-associated membranes and mediates cardioprotection
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abo1244
Abstract: Mitochondrial-associated membranes (MAMs) are known to modulate organellar and cellular functions and can subsequently affect pathophysiology including myocardial ischemia-reperfusion (IR) injury. Thus, identifying molecular targets in MAMs that regulate the outcome of IR injury will… read more here.
Keywords: localizes mitochondrial; mitochondrial associated; clic4; injury ... See more keywords
Host CLIC4 expression in the tumor microenvironment is essential for breast cancer metastatic competence
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DOI: 10.1371/journal.pgen.1010271
Abstract: The TGF-β-regulated Chloride Intracellular Channel 4 (CLIC4) is an essential participant in the formation of breast cancer stroma. Here, we used data available from the TCGA and METABRIC datasets to show that CLIC4 expression was… read more here.
Keywords: clic4 expression; clic4; breast; breast cancer ... See more keywords
The stromal immunoexpression of CLIC4 may be related to the difference in the biological behavior between oral squamous cell carcinoma and oral verrucous carcinoma.
Sign Up to like & getrecommendations! Published in 2023 at "Medicina oral, patologia oral y cirugia bucal"
DOI: 10.4317/medoral.25842
Abstract: BACKGROUND Oral squamous cell carcinoma (OSCC) has high morbidity and mortality rates while oral verrucous carcinoma (OVC), an uncommon variant of OSCC, exhibits a distinct biological behavior. CLIC4 protein plays a role in the cell… read more here.
Keywords: cell; biological behavior; clic4; stroma ... See more keywords