Synthesis of 1,2,3-triazole-1,3,4-thiadiazole hybrids as novel α-glucosidase inhibitors by in situ azidation/click assembly.
Sign Up to like & getrecommendations! Published in 2023 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202300145
Abstract: α-Glucosidase inhibition is widely used in the oral management of diabetes mellitus (DM), a disease characterized by high blood sugar levels (hyperglycemia) and abnormal carbohydrate metabolism. In this respect, a series of 1,2,3-triazole-1,3,4-thiadiazole hybrids 7a-j… read more here.
Keywords: glucosidase; triazole thiadiazole; click assembly; thiadiazole hybrids ... See more keywords
Three-step click assembly using trivalent platforms bearing azido, ethynyl, and fluorosulfonyl groups.
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DOI: 10.1039/d4cc06585a
Abstract: Divergent synthesis of triazoles was achieved using newly designed platform molecules possessing azide, alkyne, and fluorosulfonyl moieties. Consecutive conjugations by the sulfur(VI) fluoride exchange and following consecutive triazole formations allowed us to prepare a wide… read more here.
Keywords: step click; assembly using; three step; click assembly ... See more keywords
Rapid synthesis of PROTACs by consecutive click assembly
Sign Up to like & getrecommendations! Published in 2025 at "Bulletin of the Chemical Society of Japan"
DOI: 10.1093/bulcsj/uoaf115
Abstract: An efficient strategy to access proteolysis-targeting chimeras (PROTACs) is disclosed. Consecutive click assembly of readily available functional modules enables the rapid and modular synthesis of PROTACs. In this manuscript, we demonstrate the synthesis of a… read more here.
Keywords: consecutive click; synthesis; synthesis protacs; click assembly ... See more keywords