Development of a Cancer Vaccine Using In Vivo Click-Chemistry-Mediated Active Lymph Node Accumulation for Improved Immunotherapy.
Sign Up to like & getrecommendations! Published in 2021 at "Advanced materials"
DOI: 10.1002/adma.202006007
Abstract: Due to their ability to elicit a potent immune reaction with low systemic toxicity, cancer vaccines represent a promising strategy for treating tumors. Considerable effort has been directed toward improving the in vivo efficacy of… read more here.
Keywords: click chemistry; chemistry; lymph node; cancer ... See more keywords
Click chemistry based regioselective one‐pot synthesis of coumarin‐3‐yl‐methyl‐1,2,3‐triazolyl‐1,2,4‐triazol‐3(4H)‐ones as newer potent antitubercular agents
Sign Up to like & getrecommendations! Published in 2019 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.201900013
Abstract: Coumarin‐3‐yl‐methyl‐1,2,3‐triazolyl‐1,2,4‐triazol‐3(4H)‐ones (8k‐z) were synthesized via copper(I)‐catalyzed azide‐alkyne cycloaddition click chemistry. The synthesized hybrid molecules were characterized by spectral studies. Compounds 8k‐z were screened for their in vitro anti‐TB activity by using the Microplate Alamar Blue… read more here.
Keywords: click chemistry; chemistry; triazol ones; coumarin methyl ... See more keywords
Supersensitive Multifluorophore RNA‐FISH for Early Virus Detection and Flow‐FISH by Using Click Chemistry
Sign Up to like & getrecommendations! Published in 2020 at "Chembiochem"
DOI: 10.1002/cbic.202000081
Abstract: The reliable detection of transcription events through the quantification of the corresponding mRNA is of paramount importance for the diagnostics of infections and diseases. The quantification and localization analysis of the transcripts of a particular… read more here.
Keywords: detection; click chemistry; supersensitive multifluorophore; chemistry ... See more keywords
Development of Tetrameric N-Annulated Perylene Diimides Using "Click" Chemistry.
Sign Up to like & getrecommendations! Published in 2022 at "ChemSusChem"
DOI: 10.1002/cssc.202200492
Abstract: Herein, we report the design, synthesis, and characterization of two novel N-annulated perylene diimide (NPDI) tetramer arrays that were developed using copper catalyzed alkyne-azide cycloaddition. Despite the optoelectronic properties of both tetramers being nearly identical,… read more here.
Keywords: click chemistry; development; chemistry; using click ... See more keywords
Click chemistry‐based synthesis of new benzenesulfonamide derivatives bearing triazole ring as selective carbonic anhydrase II inhibitors
Sign Up to like & getrecommendations! Published in 2022 at "Drug Development Research"
DOI: 10.1002/ddr.21957
Abstract: A series of 1,2,3‐triazol‐1‐ylbenzenesulfonamide derivatives was designed, synthesized and their ability to inhibit several carbonic anhydrase isoforms was evaluated. The basis of our design is to hybridize the benzenesulfonamide moiety widely used as a zinc‐binding… read more here.
Keywords: click chemistry; carbonic anhydrase; triazole ring; chemistry ... See more keywords
A Practical Synthesis of Valuable Strained Eight‐Membered‐Ring Derivatives for Click Chemistry
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Organic Chemistry"
DOI: 10.1002/ejoc.201800139
Abstract: A convenient and cost-effective synthetic access to cyclooctyne and trans-cyclooctene derivatives is described. A cyclopropanation step using copper powder in lieu of Rh₂(OAc)₄ as catalyst and a symmetric diazomalonate enabled to drastically reduce the overall… read more here.
Keywords: click chemistry; practical synthesis; chemistry; chemistry practical ... See more keywords
1H-1,2,3-Triazole: From Structure to Function and Catalysis
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Heterocyclic Chemistry"
DOI: 10.1002/jhet.2770
Abstract: The heterocyclic family of azoles have recently become one of the most widely used members of the N-heterocycles; the most prominent one being 1H-1,2,3-triazole and its derivatives. The sudden growth of interest in this structural… read more here.
Keywords: click chemistry; triazole; triazole structure; chemistry ... See more keywords
Novel Anti-Biofouling Soft Contact Lens: l-Cysteine Conjugated Amphiphilic Conetworks via RAFT and Thiol-Ene Click Chemistry.
Sign Up to like & getrecommendations! Published in 2017 at "Macromolecular bioscience"
DOI: 10.1002/mabi.201600444
Abstract: A unique l-cysteine conjugated antifouling amphiphilic conetwork (APCN) is synthesized through end-crosslinking of well-defined triblock copolymers poly(allyl methacrylate)-b-poly(ethylene glycol)-b-poly(allyl methacrylate) via a combination of reversible addition-fragmentation chain transfer (RAFT) polymerization and thiol-ene "click" chemistry. The… read more here.
Keywords: click chemistry; raft; cysteine; chemistry ... See more keywords
Click Chemistry in Functional Aliphatic Polycarbonates.
Sign Up to like & getrecommendations! Published in 2017 at "Macromolecular rapid communications"
DOI: 10.1002/marc.201700357
Abstract: Click chemistry, one of the most important methods in conjugation, plays an extremely significant role in the synthesis of functional aliphatic polycarbonates, which are a group of biodegradable polymers containing carbonate bonds in their main… read more here.
Keywords: aliphatic polycarbonates; chemistry functional; click chemistry; functional aliphatic ... See more keywords
Contribution of the "Click Chemistry" Toolbox for the Design, Synthesis and Resulting Applications of Innovative and Efficient Separative Supports: Time for assessment.
Sign Up to like & getrecommendations! Published in 2022 at "Macromolecular rapid communications"
DOI: 10.1002/marc.202200210
Abstract: The last two decades have seen the rapid expansion of click chemistry methodology in various domains closely related to organic chemistry. It has notably been widely developed in the area of surface chemistry, mainly because… read more here.
Keywords: design synthesis; chemistry; click chemistry; toolbox ... See more keywords
Electrically Controlled Click-Chemistry for Assembly of Bioactive Hydrogels on Diverse Micro- and Flexible Electrodes.
Sign Up to like & getrecommendations! Published in 2022 at "Macromolecular rapid communications"
DOI: 10.1002/marc.202200557
Abstract: The seamless integration of electronics with living matter requires advanced materials with programmable biological and engineering properties. Here we explore electrochemical methods to assemble semi-synthetic hydrogels directly on electronically conductive surfaces. We polymerize hydrogels consisting… read more here.
Keywords: click chemistry; assembly bioactive; chemistry assembly; controlled click ... See more keywords