Development of a Bioorthogonal Click-to-Release Reaction for Hydrogen Polysulfide (H2Sn) Detection.
Sign Up to like & getrecommendations! Published in 2024 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.4c02677
Abstract: In this study, we present an innovative "click-to-release" strategy for the design of highly specific H2Sn bioorthogonal probes that undergo a specific click reaction with H2Sn and release fluorophores by a following rearrangement. A library… read more here.
Keywords: reaction; release; click release; h2sn detection ... See more keywords
Easy Access to Bioorthogonal Click-to-Release Reagent Bishydroxy-trans-cyclooctene (C2TCO) and Harnessing of Its Rapid Labeling and Dissecting Feature in Multicycle Imaging.
Sign Up to like & getrecommendations! Published in 2025 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.4c00495
Abstract: Bifunctional trans-cyclooctene (bTCO) with a carbamate or carbonate at the allylic position and tetrazine provide a promising bioorthogonal click chemistry pair for the click-to-release approach, successfully employed in various biotechnological applications. Herein, we demonstrate a… read more here.
Keywords: chemistry; bioorthogonal click; click; click release ... See more keywords
Development of Cyclooctyne-Nitrone Based Click Release Chemistry for Bioorthogonal Prodrug Activation both In Vitro and In Vivo.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.5c08152
Abstract: The advancement of bioorthogonal cleavage platforms has emerged as a critical frontier in chemical biology, offering precise molecular liberation through physiologically compatible activation mechanisms. Despite its significant potential, ensuring efficacy in vivo typically requires rapid… read more here.
Keywords: chemistry; vivo; release; activation ... See more keywords
Tetrazine-induced activation of a trimethyl lock as a click-to-release system for protected doxorubicin.
Sign Up to like & getrecommendations! Published in 2023 at "Chemical communications"
DOI: 10.1039/d3cc01334k
Abstract: We herein report a novel chemically triggered click-to-release system, that combines the trimethyl lock (TML) lactonization with the bioorthogonal inverse electron demand Diels-Alder (IEDDA) reaction of a vinyl ether and a tetrazine. Kinetic studies were… read more here.
Keywords: system; click release; release system; tetrazine ... See more keywords
Abstract 3486: Click-to-release for controlled immune cell activation: tumor-targeted unmasking of an IL-12 prodrug in vivo
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Research"
DOI: 10.1158/1538-7445.am2025-3486
Abstract: Immunotherapy utilizing immune stimulating cytokines such as IL-12 holds great promise for the treatment of cancer. However, clinical use of IL-12 is hampered by severe toxicity following systemic administration resulting in a narrow therapeutic window.… read more here.
Keywords: tumor targeted; tumor; click release; activation tumor ... See more keywords
Click-to-Release for Controlled Immune Cell Activation: Tumor-Targeted Unmasking of an IL12 Prodrug
Sign Up to like & getrecommendations! Published in 2025 at "Pharmaceuticals"
DOI: 10.3390/ph18091380
Abstract: Objectives: Immunotherapy utilizing immune-stimulating cytokines such as IL12 holds great promise for the treatment of cancer. However, clinical use of IL12 is hampered due to severe toxicity following systemic administration. We here present a novel… read more here.
Keywords: reaction; tumor; click release; activation ... See more keywords
Initial Steps towards Spatiotemporal Signaling through Biomaterials Using Click-to-Release Chemistry
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics14101991
Abstract: The process of wound healing is a tightly controlled cascade of events, where severe skin wounds are resolved via scar tissue. This fibrotic response may be diminished by applying anti-fibrotic factors to the wound, thereby… read more here.
Keywords: wound healing; click release; chemistry; release chemistry ... See more keywords