Tetrazine-induced activation of a trimethyl lock as a click-to-release system for protected doxorubicin.
Sign Up to like & getrecommendations! Published in 2023 at "Chemical communications"
DOI: 10.1039/d3cc01334k
Abstract: We herein report a novel chemically triggered click-to-release system, that combines the trimethyl lock (TML) lactonization with the bioorthogonal inverse electron demand Diels-Alder (IEDDA) reaction of a vinyl ether and a tetrazine. Kinetic studies were… read more here.
Keywords: system; click release; release system; tetrazine ... See more keywords
Initial Steps towards Spatiotemporal Signaling through Biomaterials Using Click-to-Release Chemistry
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DOI: 10.3390/pharmaceutics14101991
Abstract: The process of wound healing is a tightly controlled cascade of events, where severe skin wounds are resolved via scar tissue. This fibrotic response may be diminished by applying anti-fibrotic factors to the wound, thereby… read more here.
Keywords: wound healing; click release; chemistry; release chemistry ... See more keywords