Phosphorylation induced cochaperone unfolding promotes kinase recruitment and client class-specific Hsp90 phosphorylation
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DOI: 10.1038/s41467-017-02711-w
Abstract: During the Hsp90-mediated chaperoning of protein kinases, the core components of the machinery, Hsp90 and the cochaperone Cdc37, recycle between different phosphorylation states that regulate progression of the chaperone cycle. We show that Cdc37 phosphorylation… read more here.
Keywords: hsp90 phosphorylation; client; cochaperone; client class ... See more keywords