Fragment Screening Yields a Small‐Molecule Stabilizer of 14‐3‐3 Dimers That Modulates Client Protein Interactions
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DOI: 10.1002/cbic.202200178
Abstract: The development of protein‐protein interaction (PPI) inhibitors has been a successful strategy in drug development. However, the identification of PPI stabilizers has proven much more challenging. Here we report a fragment‐based drug screening approach using… read more here.
Keywords: client protein; fragment screening; stabilizer; protein interactions ... See more keywords
Protein folding while chaperone bound is dependent on weak interactions
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DOI: 10.1038/s41467-019-12774-6
Abstract: It is generally assumed that protein clients fold following their release from chaperones instead of folding while remaining chaperone-bound, in part because binding is assumed to constrain the mobility of bound clients. Previously, we made… read more here.
Keywords: client protein; spy; client; chaperone bound ... See more keywords
Late Embryogenesis Abundant Protein–Client Protein Interactions
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DOI: 10.3390/plants9070814
Abstract: The intrinsically disordered proteins belonging to the LATE EMBRYOGENESIS ABUNDANT protein (LEAP) family have been ascribed a protective function over an array of intracellular components. We focus on how LEAPs may protect a stress-susceptible proteome.… read more here.
Keywords: protein; client protein; late embryogenesis; client ... See more keywords