Multifunctional P450 Monooxygenase CftA Diversifies the Clifednamide Pool through Tandem C-H Bond Activations.
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DOI: 10.1021/acs.jnatprod.1c00606
Abstract: Polycyclic tetramate macrolactams (PTMs) are a class of structurally complex hybrid polyketide-nonribosomal peptide (PK-NRP) natural products produced by diverse bacteria. Several PTMs display pharmaceutically interesting bioactivities, and the early stages of PTM biosynthesis involving polyketide… read more here.
Keywords: multifunctional p450; p450 monooxygenase; cfta; clifednamide ... See more keywords