Maturation of Cerebellar Purkinje Cell Population Activity during Postnatal Refinement of Climbing Fiber Network.
Sign Up to like & getrecommendations! Published in 2017 at "Cell reports"
DOI: 10.1016/j.celrep.2017.10.101
Abstract: Neural circuits undergo massive refinements during postnatal development. In the developing cerebellum, the climbing fiber (CF) to Purkinje cell (PC) network is drastically reshaped by eliminating early-formed redundant CF to PC synapses. To investigate the… read more here.
Keywords: network; population activity; cell; activity ... See more keywords
Propofol facilitates climbing fiber-Purkinje cell synaptic transmission via NMDA receptor in vitro in mice.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2020.173474
Abstract: Propofol is generally used for the induction and maintenance of anesthesia in clinical procedures via activation of γ -aminobutyric acid A (GABAA) receptors. When administered at the clinical dose, propofol use is associated with movement… read more here.
Keywords: propofol; propofol induced; synaptic transmission; cell ... See more keywords
Activation CRF-R2 augments cerebellar climbing fiber-Purkinje cell synaptic transmission via presynaptic PKA pathway in mice
Sign Up to like & getrecommendations! Published in 2022 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2022.136584
Abstract: Corticotropin releasing factor (CRF) type 2 receptor (CRF-R2) is present in climbing fiber (CF) afferents, which involves in modulating the CF-Purkinje cell (PC) synaptic transmission in cerebellar cortex. However, the role of CRF-R2 in regulating… read more here.
Keywords: pka; crf; purkinje cell; synaptic transmission ... See more keywords
Conversion of Graded Presynaptic Climbing Fiber Activity into Graded Postsynaptic Ca2+ Signals by Purkinje Cell Dendrites
Sign Up to like & getrecommendations! Published in 2019 at "Neuron"
DOI: 10.1016/j.neuron.2019.03.010
Abstract: The brain must make sense of external stimuli to generate relevant behavior. We used a combination of in vivo approaches to investigate how the cerebellum processes sensory-related information. We found that the inferior olive encodes contexts… read more here.
Keywords: cell dendrites; ca2 signals; purkinje cell; activity ... See more keywords
Coordinated cerebellar climbing fiber activity signals learned sensorimotor predictions
Sign Up to like & getrecommendations! Published in 2018 at "Nature Neuroscience"
DOI: 10.1038/s41593-018-0228-8
Abstract: The prevailing model of cerebellar learning states that climbing fibers (CFs) are both driven by, and serve to correct, erroneous motor output. However, this model is grounded largely in studies of behaviors that utilize hardwired… read more here.
Keywords: cerebellar climbing; coordinated cerebellar; activity signals; fiber activity ... See more keywords
Optical Fiber-Based Recording of Climbing Fiber Ca2+ Signals in Freely Behaving Mice
Sign Up to like & getrecommendations! Published in 2022 at "Biology"
DOI: 10.3390/biology11060907
Abstract: Simple Summary In this study, we established a robust and accessible method to chronically record calcium signals from climbing fiber (CF) projections to the cerebellar cortex in freely behaving mice. This technique was demonstrated with… read more here.
Keywords: ca2 signals; climbing fiber; fiber; optical fiber ... See more keywords