Biochemical and clinical biomarkers in adult SMA 3–4 patients treated with nusinersen for 22 months
Sign Up to like & getrecommendations! Published in 2022 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.51625
Abstract: To investigate biomarkers of disease progression in cerebrospinal fluid (CSF) and serum in adult patients with spinal muscular atrophy (SMA). Furthermore, we assess the clinical response to nusinersen treatment in adults with SMA over a… read more here.
Keywords: adult sma; biochemical clinical; clinical biomarkers; patients treated ... See more keywords
MicroRNAs in hypertrophic cardiomyopathy: pathogenesis, diagnosis, treatment potential and roles as clinical biomarkers
Sign Up to like & getrecommendations! Published in 2022 at "Heart Failure Reviews"
DOI: 10.1007/s10741-022-10231-z
Abstract: Hypertrophic cardiomyopathy (HCM) is the most common heritable cardiomyopathy and is characterized by increased left ventricular wall thickness, but existing diagnostic and treatment approaches face limitations. MicroRNAs (miRNAs) are type of noncoding RNA molecule that… read more here.
Keywords: hypertrophic cardiomyopathy; cardiomyopathy pathogenesis; treatment; pathogenesis diagnosis ... See more keywords
The spectrum of clinical biomarkers in severe malaria and new avenues for exploration
Sign Up to like & getrecommendations! Published in 2022 at "Virulence"
DOI: 10.1080/21505594.2022.2056966
Abstract: ABSTRACT Globally, malaria is a public health concern, with severe malaria (SM) contributing a major share of the disease burden in malaria endemic countries. In this context, identification and validation of SM biomarkers are essential… read more here.
Keywords: clinical biomarkers; biomarkers severe; severe malaria; validation biomarkers ... See more keywords
Umbilical cord plasma concentrate has beneficial effects on DNA methylation GrimAge and human clinical biomarkers
Sign Up to like & getrecommendations! Published in 2022 at "Aging Cell"
DOI: 10.1111/acel.13696
Abstract: Plasma transfusions are standard treatments to replace missing proteins in people with rare genetic diseases. Prior studies have demonstrated that heterochronic parabiosis has beneficial effects on several tissues of old animals receiving young blood. Human… read more here.
Keywords: plasma concentrate; clinical biomarkers; umbilical cord; human clinical ... See more keywords
Natural history and clinical biomarkers of progression in X‐linked retinitis pigmentosa: a systematic review
Sign Up to like & getrecommendations! Published in 2020 at "Acta Ophthalmologica"
DOI: 10.1111/aos.14662
Abstract: X‐linked retinitis pigmentosa (XLRP) accounts for a significant proportion of certifiable blindness in working‐age adults. The objectives of this study were to: (1) synthesize the best available evidence regarding the natural history of disease progression… read more here.
Keywords: systematic review; linked retinitis; retinitis pigmentosa; natural history ... See more keywords
Exosome-Encapsulated miR-31, miR-192, and miR-375 Serve as Clinical Biomarkers of Gastric Cancer
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Oncology"
DOI: 10.1155/2023/7335456
Abstract: In recent years, microRNAs (miRNAs) derived from exosomes have been attracting attention as novel clinical biomarkers in a variety of cancers. In this study, plasma samples from 60 gastric cancer (GC) patients and 63 healthy… read more here.
Keywords: clinical biomarkers; mir 375; 192 mir; mir 192 ... See more keywords
Establishing the criterion validity of self-report measures of adherence in hemodialysis through associations with clinical biomarkers: A systematic review and meta-analysis
Sign Up to like & getrecommendations! Published in 2022 at "PLoS ONE"
DOI: 10.1371/journal.pone.0276163
Abstract: Accurate measurement of adherence is crucial to rigorously evaluate interventions aimed at improving this outcome in patients undergoing in-center hemodialysis. Previous research has shown great variability in non-adherence rates between studies, mainly due to the… read more here.
Keywords: criterion validity; hemodialysis; adherence; clinical biomarkers ... See more keywords
Oral microbiome correlates with selected clinical biomarkers in individuals with no significant systemic disease
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2023.1114014
Abstract: The oral microbiome is an important component of the microbiome in the human body. Although the association of the oral microbiome with various diseases, including periodontitis and cancer, has been reported, information on how the… read more here.
Keywords: oral microbiome; clinical biomarkers; microbiome correlates; selected clinical ... See more keywords
Experimental and Clinical Biomarkers for Progressive Evaluation of Neuropathology and Therapeutic Interventions for Acute and Chronic Neurological Disorders
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DOI: 10.3390/ijms231911734
Abstract: This article describes commonly used experimental and clinical biomarkers of neuronal injury and neurodegeneration for the evaluation of neuropathology and monitoring of therapeutic interventions. Biomarkers are vital for diagnostics of brain disease and therapeutic monitoring.… read more here.
Keywords: therapeutic interventions; clinical biomarkers; disease; brain ... See more keywords
Evaluation of Clinical Biomarkers Related to CD4 Recovery in HIV-Infected Patients—5-Year Observation
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DOI: 10.3390/v14102287
Abstract: Human Immunodeficiency Virus infection leads to the impairment of immune system function. Even long-term antiretroviral therapy uncommonly leads to the normalization of CD4 count and CD4:CD8 ratio. The aim of this study was to evaluate… read more here.
Keywords: hiv; clinical biomarkers; cd4; infection ... See more keywords
A Review of Recent Evidence from Meal-Based Diet Interventions and Clinical Biomarkers for Improvement of Glucose Regulation
Sign Up to like & getrecommendations! Published in 2020 at "Preventive Nutrition and Food Science"
DOI: 10.3746/pnf.2020.25.1.9
Abstract: In recent decades, the prevalence of diabetes has rapidly increased worldwide. Medical nutrition therapy has been identified as a major therapeutic support for diabetic patients, while preventive strategies in prediabetic or high-risk individuals have mainly… read more here.
Keywords: meal based; review; clinical biomarkers; glucose regulation ... See more keywords