In Vitro Evaluation of Clinical Candidates of γ-Secretase Inhibitors: Effects on Notch Inhibition and Promoting Beige Adipogenesis and Mitochondrial Biogenesis.
Sign Up to like & getrecommendations! Published in 2020 at "Pharmaceutical research"
DOI: 10.1007/s11095-020-02916-7
Abstract: PURPOSE Inhibition of Notch signaling has been recently demonstrated to promote beige adipocyte biogenesis. However, most γ-secretase inhibitors (GSIs) used to achieve pharmacological inhibition of Notch signaling are at the basic research or preclinical stage,… read more here.
Keywords: secretase inhibitors; inhibition; clinical candidates; notch inhibition ... See more keywords
An Analysis of Successful Hit-to-Clinical Candidate Pairs.
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DOI: 10.1021/acs.jmedchem.3c00521
Abstract: An analysis of 156 published clinical candidates from the Journal of Medicinal Chemistry between 2018 and 2021 was conducted to identify lead generation strategies most frequently employed leading to drug candidates. As in a previous… read more here.
Keywords: clinical candidate; hit clinical; chemistry; analysis ... See more keywords
Clinical Candidates Targeting the ATR–CHK1–WEE1 Axis in Cancer
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DOI: 10.3390/cancers13040795
Abstract: Simple Summary Selective killing of cancer cells is privileged mainstream in cancer treatment and targeted therapy represents the new tool with a potential to pursue this aim. It can also aid to overcome resistance of… read more here.
Keywords: chk1 wee1; atr chk1; clinical candidates; cancer cells ... See more keywords