A Clinical Cassette Dosing Study for Evaluating the Contribution of Hepatic OATPs and CYP3A to Drug-Drug Interactions
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DOI: 10.1007/s11095-017-2168-5
Abstract: PurposeTo demonstrate the relative importance of organic anion-transporting polypeptides (OATPs) and cytochrome P450 3A (CYP3A) in the hepatic elimination of substrate drugs.MethodsA cocktail of subtherapeutic doses of bosentan, repaglinide, clarithromycin, darunavir, simeprevir, and midazolam (CYP3A… read more here.
Keywords: drug interactions; cyp3a; clinical cassette; study ... See more keywords