Distribution of microRNA profiles in pre-clinical and clinical forms of murine and human prion disease
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DOI: 10.1038/s42003-021-01868-x
Abstract: Prion diseases are distinguished by long pre-clinical incubation periods during which prions actively propagate in the brain and cause neurodegeneration. In the pre-clinical stage, we hypothesize that upon prion infection, transcriptional changes occur that can… read more here.
Keywords: clinical forms; prion; forms murine; disease ... See more keywords
Neuroprotective properties of vitamin C: A Scoping Review of pre-clinical and clinical studies.
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DOI: 10.1089/neu.2020.7443
Abstract: There is a need for novel neuroprotective therapies. We aimed to review the evidence for exogenous vitamin C as a neuroprotective agent. MEDLINE, Embase and Cochrane library databases were searched from inception to May 2020.… read more here.
Keywords: clinical studies; animal studies; clinical clinical; pre clinical ... See more keywords
Mapping the long rocky road to effective spinal cord injury therapy - A meta-review of pre-clinical and clinical research.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of neurotrauma"
DOI: 10.1089/neu.2021.0298
Abstract: Spinal cord injury (SCI) is a rare condition, which even after decades of research, to date still presents an incurable condition with a complex symptomatology. SCI can result in paralysis, pain, loss of sensation, bladder… read more here.
Keywords: clinical clinical; cord injury; therapy; pre clinical ... See more keywords
Neurotrophic Factors in Parkinson's Disease: What Have we Learned from Pre-Clinical and Clinical Studies?
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DOI: 10.2174/0929867325666180313101536
Abstract: BACKGROUND Parkinson´s Disease (PD) is a chronic, progressive condition, being the second most common neurodegenerative disorder worldwide. The classical features include: bradykinesia, resting tremor, rigidity and festination. These neurological alterations are probably due to the… read more here.
Keywords: clinical studies; clinical clinical; pre clinical; parkinson disease ... See more keywords
Stem cells application in meniscal tears: a systematic review of pre-clinical and clinical evidence.
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DOI: 10.26355/eurrev_202112_27622
Abstract: OBJECTIVE Conservative and surgical treatments for meniscal lesions are various and this field of orthopedic surgery is in continuous development. Stem cells represent one of the current options to stimulate meniscal healing. The present systematic… read more here.
Keywords: pre clinical; clinical clinical; stem; stem cells ... See more keywords
Remimazolam: Non-Clinical and Clinical Profile of a New Sedative/Anesthetic Agent
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DOI: 10.3389/fphar.2021.690875
Abstract: A program to identify novel intravenous sedatives with a short and predictable duration of action was initiated in the late 1990’s by Glaxo Wellcome. The program focussed on the identification of ester-based benzodiazepine derivatives that… read more here.
Keywords: program; remimazolam; pharmacology; clinical clinical ... See more keywords
Clinical and Clinical Pathological Presentation of 310 Dogs Affected by Lymphoma with Aberrant Antigen Expression Identified via Flow Cytometry
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DOI: 10.3390/vetsci9040184
Abstract: Phenotypic aberrancies have been reported occasionally in canine lymphomas. Here, we retrospectively collected 310 canine lymphomas with an aberrant phenotype detected via flow cytometry and describe their clinical and clinical pathological features at diagnosis. There… read more here.
Keywords: clinical pathological; flow cytometry; lymphomas; cell lymphomas ... See more keywords
Factors influencing the transition of pharmacy students from pre-clinical to clinical years at university
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DOI: 10.46542/pe.2020.201.336345
Abstract: Introduction: The transition to clinical studies can be a source of stress, though little is known about how pharmacy students manage this transition. This mixed-methods study investigated factors influencing student transition from pre-clinical to clinical… read more here.
Keywords: transition; clinical clinical; pharmacy; pre clinical ... See more keywords