Abstract 5566: LYC-55716, a first-in-class RORγ agonist: Rationale and preclinical data to support clinical combinations with established immunotherapies
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DOI: 10.1158/1538-7445.am2018-5566
Abstract: The retinoic acid-related orphan receptor γt (RORγt) is a nuclear receptor transcription factor that acts as an immune cell master control switch driving the generation and function of Th17 (helper) and Tc17 (cytotoxic) T cells.… read more here.
Keywords: clinical combinations; ror; ror agonist; lyc 55716 ... See more keywords