Hereditary Retinal Dystrophy.
Sign Up to like & getrecommendations! Published in 2017 at "Handbook of experimental pharmacology"
DOI: 10.1007/164_2016_91
Abstract: As our understanding of the genetic basis for inherited retinal disease has expanded, gene therapy has advanced into clinical development. When the gene mutations associated with inherited retinal dystrophies were identified, it became possible to… read more here.
Keywords: hereditary retinal; clinical development; disease; gene ... See more keywords
Perspectives on the Clinical Development of NRF2-Targeting Drugs.
Sign Up to like & getrecommendations! Published in 2020 at "Handbook of experimental pharmacology"
DOI: 10.1007/164_2020_381
Abstract: The transcription factor NRF2 (nuclear factor erythroid 2-related factor 2) triggers homeostatic responses against a plethora of environmental or endogenous deviations in redox metabolism, inflammation, proteostasis, etc. Therefore, pharmacological activation of NRF2 is a promising… read more here.
Keywords: clinical development; development; factor; development nrf2 ... See more keywords
Cardiovascular Outcome Trials of Diabetes and Obesity Drugs: Implications for Conditional Approval and Early Phase Clinical Development
Sign Up to like & getrecommendations! Published in 2017 at "Pharmaceutical Medicine"
DOI: 10.1007/s40290-017-0209-3
Abstract: Over the past decade, clinical development and regulatory review of investigational drugs for diabetes and obesity have been guided by heightened standards for pre- and post-marketing assessment of cardiovascular safety. In high-risk patients with type… read more here.
Keywords: risk; diabetes obesity; clinical development; cardiovascular safety ... See more keywords
The pipeline of targeted therapies under clinical development for primary Sjögren's syndrome: A systematic review of trials.
Sign Up to like & getrecommendations! Published in 2019 at "Autoimmunity reviews"
DOI: 10.1016/j.autrev.2018.12.008
Abstract: To date, no immunomodulatory drug has proved efficacious in primary Sjögren's syndrome (pSS). In pSS, difficulties in drug efficacy assessment is related to the large spectrum of clinical involvements (glandular/extraglandular involvement), to the lack of… read more here.
Keywords: gren syndrome; clinical development; pss; primary gren ... See more keywords
Practical considerations of utilizing propensity score methods in clinical development utilizing real-world and historical data.
Sign Up to like & getrecommendations! Published in 2020 at "Contemporary clinical trials"
DOI: 10.1016/j.cct.2020.106123
Abstract: In recent years, with the rapid increase in the volume and accessibility of Real-World-Data (RWD) and Real-World-Evidence (RWE), we have seen the unprecedented opportunities for their use in drug clinical development and life-cycle management. RWD… read more here.
Keywords: clinical development; propensity; propensity score; score methods ... See more keywords
Peptides in clinical development for the treatment of brain tumors.
Sign Up to like & getrecommendations! Published in 2019 at "Current opinion in pharmacology"
DOI: 10.1016/j.coph.2019.02.007
Abstract: Peptides have emerged as novel and promising medicaments for the treatment of many human diseases, including tumors. In the treatment of cancer, they can be employed directly as bioactive therapeutics, promoting the reduction of tumor… read more here.
Keywords: clinical development; treatment; brain; development treatment ... See more keywords
Correlates of time to approval and other clinical development periods.
Sign Up to like & getrecommendations! Published in 2019 at "Drug discovery today"
DOI: 10.1016/j.drudis.2019.05.027
Abstract: The drug development cycle is classically divided into a clinical phase and review phase, with the clinical phase typically being further partitioned based on the planning and conduct of adequate and well controlled trials. Factors… read more here.
Keywords: approval clinical; clinical development; drug; time approval ... See more keywords
Modulators of CFTR. Updates on clinical development and future directions.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2021.113195
Abstract: Cystic fibrosis (CF) is the most frequent life-limiting autosomal recessive disorder in the Caucasian population. It is due to mutations in the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene. Current symptomatic CF therapies, which treat… read more here.
Keywords: cftr updates; development future; clinical development; future directions ... See more keywords
The clinical development of carboplatin – A personal perspective
Sign Up to like & getrecommendations! Published in 2019 at "Inorganica Chimica Acta"
DOI: 10.1016/j.ica.2019.118987
Abstract: Abstract Following the breakthrough discovery of cisplatin, carboplatin was developed as a less toxic analogue, acting by the same mechanism. Early clinical studies showed that it largely lacked the nephron-, oto-, and neurotoxicity of cisplatin… read more here.
Keywords: development; carboplatin personal; carboplatin; clinical development ... See more keywords
Topical Fixed-Dose Combinations: Current in vitro methodologies for pre-clinical development.
Sign Up to like & getrecommendations! Published in 2022 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2022.121621
Abstract: The combination of two or more active pharmaceutical ingredients in the same dosage form - fixed-dose combination products - for topical administration represents a promising therapeutic approach for treating several pathologies, including pain. The pre-clinical… read more here.
Keywords: pre clinical; fixed dose; clinical development; dose combination ... See more keywords
Inhibition of Akt and other AGC kinases: A target for clinical cancer therapy?
Sign Up to like & getrecommendations! Published in 2018 at "Seminars in cancer biology"
DOI: 10.1016/j.semcancer.2017.04.011
Abstract: AGC kinases have been identified to contribute to cancer development and progression. Currently, most AGC inhibitors in clinical development are Akt inhibitors such as MK-2206 or GDC-0068, which are known to promote cell growth arrest… read more here.
Keywords: inhibition akt; agc kinases; akt inhibitors; clinical development ... See more keywords