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   Articles with "clinical diagnostics" as a keyword



In‐vitro Clinical Diagnostics using RNA‐Cleaving DNAzymes

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recommendations! Published in 2024 at "ChemBioChem"

DOI: 10.1002/cbic.202400085

Abstract: Over the last three decades, significant advancements have been made in the development of biosensors and bioassays that use RNA‐cleaving DNAzymes (RCDs) as molecular recognition elements. While early examples of RCDs were primarily responsive to… read more here.

Keywords: rna cleaving; vitro clinical; clinical diagnostics; cleaving dnazymes ... See more keywords

Ultrasensitive Sensor Using Quantum Dots-Doped Polystyrene Nanospheres for Clinical Diagnostics of Low-Volume Serum Samples.

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recommendations! Published in 2019 at "Analytical chemistry"

DOI: 10.1021/acs.analchem.9b00010

Abstract: Development of sensitive homogeneous assays is a high-priority research target for clinical diagnostics. Quantum dots (QDs) present favorable photophysical properties, which implies their potential as an exceptional dye in fluorescence detection. QDs-based biosensors have been… read more here.

Keywords: clinical diagnostics; serum samples; quantum dots; polystyrene nanospheres ... See more keywords

ProPickML: Advancing Clinical Diagnostics with Automated Peak Picking in Label-Free Targeted Proteomics

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recommendations! Published in 2024 at "Journal of Proteome Research"

DOI: 10.1021/acs.jproteome.4c00689

Abstract: In targeted proteomics utilizing Selected Reaction Monitoring (SRM), the precise detection of specific peptides within complex mixtures remains a significant challenge, particularly due to noise and interference in chromatograms. Existing methodologies, such as isotopic labeling… read more here.

Keywords: automated peak; targeted proteomics; propickml advancing; clinical diagnostics ... See more keywords

Extracellular Vesicles for Clinical Diagnostics: From Bulk Measurements to Single-Vesicle Analysis

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recommendations! Published in 2025 at "ACS Nano"

DOI: 10.1021/acsnano.5c00706

Abstract: Extracellular vesicles (EVs) play a crucial role in intercellular communication, signaling pathways, and disease pathogenesis by transporting biomolecules such as DNA, RNA, proteins, and lipids derived from their cells of origin, and they have demonstrated… read more here.

Keywords: extracellular vesicles; analysis; bulk; clinical diagnostics ... See more keywords

Building the Future of Clinical Diagnostics: An Analysis of Potential Benefits and Current Barriers in CRISPR/Cas Diagnostics

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recommendations! Published in 2025 at "ACS Synthetic Biology"

DOI: 10.1021/acssynbio.4c00816

Abstract: Advancements in molecular diagnostics, such as polymerase chain reaction and next-generation sequencing, have revolutionized disease management and prognosis. Despite these advancements in molecular diagnostics, the field faces challenges due to high operational costs and the… read more here.

Keywords: building future; technology; diagnostics analysis; crispr cas ... See more keywords

Evaluation of measurement uncertainty in direct and estimated serum osmolality according to ISO/TS 20914: implications for clinical diagnostics

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recommendations! Published in 2025 at "Scandinavian Journal of Clinical and Laboratory Investigation"

DOI: 10.1080/00365513.2025.2487988

Abstract: Abstract This study examines the measurement uncertainties (MU) associated with osmolality (OSM), a crucial parameter in clinical diagnostics and treatment. The research compares the uncertainties of directly measured osmolality (dOSM) with those of estimated osmolality… read more here.

Keywords: chemistry; osmolality; iso 20914; clinical diagnostics ... See more keywords

1996. Addressing Pulmonary Nocardiosis Risk in Immunocompromised Patients: Development and Validation of a Commercially Available PCR

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recommendations! Published in 2018 at "Open Forum Infectious Diseases"

DOI: 10.1093/ofid/ofy210.1652

Abstract: Abstract Background Pulmonary nocardiosis is an infection targeting immunocompromised patients characterized by high mortality and requires nonfrontline antibiotics for treatment. Nocardiosis is currently confirmed or excluded by BAL fluid culture followed by further phenotypic identification… read more here.

Keywords: employee; viracor eurofins; clinical diagnostics; diagnostics employee ... See more keywords

UltraSEQ, a Universal Bioinformatic Platform for Information-Based Clinical Metagenomics and Beyond

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recommendations! Published in 2022 at "Microbiology Spectrum"

DOI: 10.1128/spectrum.04160-22

Abstract: Traditional clinical microbiology-based diagnostic tests rely on targeted methods that can detect only one to a few preselected organisms or slow, culture-based methods. Although widely used today, these methods have several limitations, resulting in rates… read more here.

Keywords: information; information based; sample; disease ... See more keywords

EVALUATION OF CLINICAL DIAGNOSTICS FOR PROVENTRICULAR NEMATODIASIS DUE TO SYNHIMANTUS NASUTA IN LORIKEETS (TRICHOGLOSSUS SPP.)

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recommendations! Published in 2022 at "Journal of Zoo and Wildlife Medicine"

DOI: 10.1638/2021-0030

Abstract: Abstract: In this case series, clinical investigations were pursued during a Synhimantus nasuta infection in a lorikeet (Trichoglossus spp.) flock outbreak situation to better describe and document clinical presentations. In 11 lorikeets suspected to be… read more here.

Keywords: synhimantus nasuta; evaluation clinical; synhimantus; diagnostics proventricular ... See more keywords
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Developments in the application of high resolution ultrasound in clinical diagnostics.

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recommendations! Published in 2017 at "Clinical hemorheology and microcirculation"

DOI: 10.3233/ch-179100

Abstract: Ernst-Michael Junga, Friedrich Jungb and Hui-Xiong Xuc aDepartment of Radiology, Interdisciplinary Ultrasound Department, University Hospital Regensburg, Regensburg, Germany bInstitute of Biomaterial Science and Berlin-Brandenburg Centre for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, Teltow, Germany cDepartment of Medical… read more here.

Keywords: high resolution; application high; clinical diagnostics; developments application ... See more keywords

Low Impact of Clonal Hematopoiesis on the Determination of RAS Mutations by Cell-Free DNA Testing in Routine Clinical Diagnostics

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recommendations! Published in 2022 at "Diagnostics"

DOI: 10.3390/diagnostics12081956

Abstract: Targeted sequencing of circulating cell-free DNA (cfDNA) is used in routine clinical diagnostics for the identification of predictive biomarkers in cancer patients in an advanced stage. The presence of KRAS mutations associated with clonal hematopoiesis… read more here.

Keywords: cell free; routine clinical; clinical diagnostics; kras mutations ... See more keywords