Strategies for clinical dose optimization of T cell-engaging therapies in oncology
Sign Up to like & getrecommendations! Published in 2023 at "mAbs"
DOI: 10.1080/19420862.2023.2181016
Abstract: ABSTRACT Innovative approaches in the design of T cell-engaging (TCE) molecules are ushering in a new wave of promising immunotherapies for the treatment of cancer. Their mechanism of action, which generates an in trans interaction… read more here.
Keywords: oncology; dose optimization; clinical dose; cell engaging ... See more keywords
P133 In vitro pharmacological profile of GLPG3667 suggests differentiation from the TYK2 inhibitors deucravacitinib and TAK-279 at their clinical dose regimens
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Crohn's and Colitis"
DOI: 10.1093/ecco-jcc/jjad212.0263
Abstract: Tyrosine kinase 2 (TYK2), a Janus kinase (JAK) family member, is attracting a lot of interest as a new target to treat patients with autoimmune and inflammatory diseases, including inflammatory bowel disease, and several inhibitors… read more here.
Keywords: dose regimens; inhibition; tyk2 inhibitors; clinical dose ... See more keywords
The estimation and translation uncertainties in applying NOAEL to clinical dose escalation
Sign Up to like & getrecommendations! Published in 2024 at "Clinical and Translational Science"
DOI: 10.1111/cts.13831
Abstract: The systemic exposure at the no‐observed‐adverse‐effect‐level (NOAEL) estimated from animals is an important criterion commonly applied to guard the safety of participants in clinical trials of investigational drugs. However, the discrepancy in toxicity profile between… read more here.
Keywords: dose escalation; toxicity; clinical dose; estimation ... See more keywords
The proteomic differences and expression of fatty acid-binding protein 6 (FABP6) associated with gastrointestinal injury in horses with oral administration of a clinical dose of phenylbutazone.
Sign Up to like & getrecommendations! Published in 2025 at "Equine veterinary journal"
DOI: 10.1111/evj.14538
Abstract: BACKGROUND Phenylbutazone (PBZ) can potentially induce gastrointestinal ulceration, and early detection of PBZ-induced gastroenteropathy will be useful for the diagnosis, treatment, and prevention of PBZ toxicity. OBJECTIVES To identify putative proteins associated with equine gastric… read more here.
Keywords: treatment; fabp6; administration; clinical dose ... See more keywords
Towards clinical-dose grating interferometry breast CT with fused intensity-based iterative reconstruction.
Sign Up to like & getrecommendations! Published in 2023 at "Optics express"
DOI: 10.1364/oe.484123
Abstract: X-ray grating interferometry CT (GI-CT) is an emerging imaging modality which provides three complementary contrasts that could increase the diagnostic content of clinical breast CT: absorption, phase, and dark-field. Yet, reconstructing the three image channels… read more here.
Keywords: breast; grating interferometry; reconstruction; clinical dose ... See more keywords
Esketamine at a Clinical Dose Attenuates Cerebral Ischemia/Reperfusion Injury by Inhibiting AKT Signaling Pathway to Facilitate Microglia M2 Polarization and Autophagy
Sign Up to like & getrecommendations! Published in 2025 at "Drug Design, Development and Therapy"
DOI: 10.2147/dddt.s504179
Abstract: Purpose This study aimed to assess the protective effect of a clinical dose esketamine on cerebral ischemia/reperfusion (I/R) injury and to reveal the potential mechanisms associated with microglial polarization and autophagy. Methods Experimental cerebral ischemia… read more here.
Keywords: cerebral ischemia; akt signaling; injury; clinical dose ... See more keywords