Use of Molecular Imaging in Clinical Drug Development: a Systematic Review
Sign Up to like & getrecommendations! Published in 2019 at "Nuclear Medicine and Molecular Imaging"
DOI: 10.1007/s13139-019-00593-y
Abstract: BackgroundMolecular imaging such as positron emission tomography (PET) and single-photon emission computed tomography (SPECT) can provide the crucial pharmacokinetic-pharmacodynamic information of a drug non-invasively at an early stage of clinical drug development. Nevertheless, not much… read more here.
Keywords: drug; drug development; molecular imaging; clinical drug ... See more keywords
Assessment of frequency and reporting of design changes among clinical drug trials published in influential medical journals.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of internal medicine"
DOI: 10.1016/j.ejim.2019.08.009
Abstract: BACKGROUND Modifications of primary outcome measures after trial initiation can undermine their scientific validity. We aimed to quantify these changes and to characterize potential predictors in clinical drug trials published in high impact factor general… read more here.
Keywords: medicine; primary outcome; drug trials; clinical drug ... See more keywords
Innovative highlights of clinical drug trial design
Sign Up to like & getrecommendations! Published in 2020 at "Translational Research"
DOI: 10.1016/j.trsl.2020.05.007
Abstract: Abstract Clinical trials serve as the gold standard to evaluate the efficacy and safety of tested drugs prior to marketing authorization. Nevertheless, there have been a few challenging issues well noted in traditional clinical trials… read more here.
Keywords: highlights clinical; trial; innovative highlights; drug ... See more keywords
Leveraging patient‐centric sampling for clinical drug development and decentralized clinical trials: Promise to reality
Sign Up to like & getrecommendations! Published in 2022 at "Clinical and Translational Science"
DOI: 10.1111/cts.13411
Abstract: Advances in the technologies to enable patient‐centric sampling (PCS) have the potential to improve blood sample collection by enabling clinical trial participants to collect samples via self‐collection or with the help of a caregiver in… read more here.
Keywords: development; patient centric; clinical drug; centric sampling ... See more keywords
Clinical Drug Trials
Sign Up to like & getrecommendations! Published in 2018 at "Pediatrics in Review"
DOI: 10.1542/pir.2016-0230
Abstract: 1. Amy Mason, MD, MSc* 1. *Bayer Pharmaceuticals, Whippany, NJ 1. Code of Federal Regulations Title 21, Part 312, Investigational New Drug Application. US Food and Drug Administration. https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfCFR/CFRSearch.cfm?CFRPart=312. Accessed January 24, 2018 2. The… read more here.
Keywords: https www; drug trials; drug; clinical drug ... See more keywords
Kidney Cancer Models for Pre-Clinical Drug Discovery: Challenges and Opportunities
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.889686
Abstract: Renal cell carcinoma (RCC) is among the most lethal urological malignancies once metastatic. The introduction of immune checkpoint inhibitors has revolutionized the therapeutic landscape of metastatic RCC, nevertheless, a significant proportion of patients will experience… read more here.
Keywords: drug discovery; rcc; clinical drug; pre clinical ... See more keywords
Challenges for Clinical Drug Development in Pulmonary Fibrosis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.823085
Abstract: Pulmonary fibrosis is a pathologic process associated with scarring of the lung interstitium. Interstitial lung diseases (ILDs) encompass a large and heterogenous group of disorders, a number of which are characterized by progressive pulmonary fibrosis… read more here.
Keywords: challenges clinical; development; pulmonary fibrosis; clinical drug ... See more keywords
Prospective Prediction of Dapaconazole Clinical Drug–Drug Interactions Using an In Vitro to In Vivo Extrapolation Equation and PBPK Modeling
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceuticals"
DOI: 10.3390/ph16010028
Abstract: This study predicted dapaconazole clinical drug–drug interactions (DDIs) over the main Cytochrome P450 (CYP) isoenzymes using static (in vitro to in vivo extrapolation equation, IVIVE) and dynamic (PBPK model) approaches. The in vitro inhibition of… read more here.
Keywords: vitro vivo; drug interactions; drug drug; clinical drug ... See more keywords
Analysis of clinical drug trials in children compared to clinical drug trials in adults, in Argentina.
Sign Up to like & getrecommendations! Published in 2019 at "Archivos argentinos de pediatria"
DOI: 10.5546/aap.2019.eng.34
Abstract: INTRODUCTION It is necessary to know the extent and subject matter of pediatric clinical drug research in Argentina and establish the differences with the adult population. OBJECTIVES To compare adult and pediatric clinical drug trials… read more here.
Keywords: child mortality; drug trials; infant child; drug ... See more keywords