A joint model for multiple dynamic processes and clinical endpoints: Application to Alzheimer's disease.
Sign Up to like & getrecommendations! Published in 2019 at "Statistics in medicine"
DOI: 10.1002/sim.8328
Abstract: As other neurodegenerative diseases, Alzheimer's disease, the most frequent dementia in the elderly, is characterized by multiple progressive impairments in the brain structure and in clinical functions such as cognitive functioning and functional disability. Until… read more here.
Keywords: dementia; joint model; alzheimer disease; model ... See more keywords
SARS-CoV-2 vaccines: Clinical endpoints and psychological perspectives: A literature review
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Infection and Public Health"
DOI: 10.1016/j.jiph.2022.03.017
Abstract: Background About 270 million cases have been confirmed, and 5.3 million fatalities Worldwide due to SARS-CoV-2. Several vaccine candidates have entered phase 3 of the clinical trial and are being investigated to provide immunity to… read more here.
Keywords: review; efficacy; vaccine efficacy; clinical endpoints ... See more keywords
Harmonization of neuropsychological and other clinical endpoints: Pitfalls and possibilities.
Sign Up to like & getrecommendations! Published in 2023 at "Neuropsychology"
DOI: 10.1037/neu0000895
Abstract: This special issue brings together different methods for improving harmonization of existing (i.e., legacy) and future research data. We expect that when these methods are fully deployed, they will benefit research on various clinical conditions… read more here.
Keywords: endpoints pitfalls; clinical endpoints; pitfalls possibilities; harmonization neuropsychological ... See more keywords
Improving pharmaceutical trials for children: a call to the pediatric academic community
Sign Up to like & getrecommendations! Published in 2018 at "Pediatric Research"
DOI: 10.1038/s41390-018-0101-1
Abstract: Pediatricians have long advocated that high-quality clinical trials must be conducted to inform proper use of medications in children. Since the passage of the Best Pharmaceuticals Act for Children (BPCA), the Pediatric Research Equity Act… read more here.
Keywords: pediatric academic; academic community; pharmaceutical trials; clinical endpoints ... See more keywords
Imaging features for the prediction of clinical endpoints in chronic liver disease: a scoping review protocol
Sign Up to like & getrecommendations! Published in 2022 at "BMJ Open"
DOI: 10.1136/bmjopen-2021-053204
Abstract: Introduction Chronic liver disease is a growing cause of morbidity and mortality in the UK. Acute presentation with advanced disease is common and prioritisation of resources to those at highest risk at earlier disease stages… read more here.
Keywords: clinical endpoints; disease; imaging features; scoping review ... See more keywords
Treatment and Clinical Endpoints in Polycythemia Vera: Seeking the Best Obtainable Version of the Truth.
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DOI: 10.1182/blood.2022015680
Abstract: Polycythemia vera (PV) is a Philadelphia chromosome-negative myeloproliferative neoplasm driven by the JAK2 V617F (or rarely exon 12) mutation. Its natural history can extend over a few decades, and therefore treatment planning is predicated on… read more here.
Keywords: clinical endpoints; treatment clinical; polycythemia vera; treatment ... See more keywords
Development of standard clinical endpoints for use in dengue interventional trials
Sign Up to like & getrecommendations! Published in 2018 at "PLoS Neglected Tropical Diseases"
DOI: 10.1371/journal.pntd.0006497
Abstract: Dengue is a major public health problem worldwide. Although several drug candidates have been evaluated in randomized controlled trials, none has been effective and at present, early recognition of severe dengue and timely supportive care… read more here.
Keywords: development standard; clinical endpoints; endpoints use; dengue ... See more keywords
Exposure to valproic acid is associated with less pulmonary infiltrates and improvements in diverse clinical outcomes and laboratory parameters in patients hospitalized with COVID-19
Sign Up to like & getrecommendations! Published in 2022 at "PLoS ONE"
DOI: 10.1371/journal.pone.0262777
Abstract: Background Valproic acid (VPA) has shown beneficial effects in vitro against SARS-CoV-2 infection, but no study has analyzed its efficacy in the clinical setting. Methods This multicenter, retrospective study included 165 adult patients receiving VPA… read more here.
Keywords: clinical endpoints; death; laboratory parameters; diverse clinical ... See more keywords