Multiomic analysis identifies a high-risk signature that predicts early clinical failure in DLBCL
Sign Up to like & getrecommendations! Published in 2024 at "Blood Cancer Journal"
DOI: 10.1038/s41408-024-01080-0
Abstract: Recent genetic and molecular classification of DLBCL has advanced our knowledge of disease biology, yet were not designed to predict early events and guide anticipatory selection of novel therapies. To address this unmet need, we… read more here.
Keywords: dlbcl; early clinical; high risk; signature ... See more keywords
Risk scoring system for the preprocedural prediction of the clinical failure of peroral endoscopic myotomy: a multicenter case–control study
Sign Up to like & getrecommendations! Published in 2022 at "Endoscopy"
DOI: 10.1055/a-1876-7554
Abstract: Abstract Background  Peroral endoscopic myotomy (POEM) is effective for the management of achalasia and its variants; however, it can be ineffective in some patients. We aimed to develop and validate a risk scoring system to… read more here.
Keywords: scoring system; risk scoring; clinical failure; failure ... See more keywords
1342. Clinical failure rates of amoxicillin for the treatment of acute otitis media in young children
Sign Up to like & getrecommendations! Published in 2020 at "Open Forum Infectious Diseases"
DOI: 10.1093/ofid/ofaa439.1524
Abstract: Acute otitis media(AOM) is the most common indication for antibiotics in children. The primary pathogens that cause AOM have changed since the introduction of the pneumococcal conjugate vaccine(PCV). The clinical failure rate of amoxicillin for… read more here.
Keywords: otitis media; clinical failure; amoxicillin treatment; treatment ... See more keywords
P-1574. Asymptomatic Bacteriuria Not a Predictor of Clinical Failure in Uncomplicated Urinary Tract Infections (uUTI): A Prospective Analysis of Women Treated for uUTI from the REASSURE Trial
Sign Up to like & getrecommendations! Published in 2025 at "Open Forum Infectious Diseases"
DOI: 10.1093/ofid/ofae631.1741
Abstract: Abstract Background Per FDA Guidance, the primary efficacy endpoint for trials evaluating antimicrobials for treatment of UTI is a combined clinical/microbiologic response. Overall success requires both resolution of UTI symptoms and demonstration that the causative… read more here.
Keywords: therapeutics stocks; iterum therapeutics; treatment; clinical failure ... See more keywords
Comparison of Outcomes in Outpatient Parenteral Antimicrobial Therapy (OPAT) Patients Receiving Vancomycin vs. Non-Vancomycin Anti-MRSA Therapy
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DOI: 10.1093/ofid/ofx163.781
Abstract: Abstract Background This evaluation set out to determine whether vancomycin therapy was associated with higher rates of clinical failure compared with non-vancomycin anti-methicillin-resistant Staphylococcus aureus therapy (NVAMT) in outpatient parenteral antimicrobial therapy (OPAT). Methods This… read more here.
Keywords: vancomycin; clinical failure; patients receiving; receiving vancomycin ... See more keywords
1010. Effectiveness of Oral Antibiotics for Definitive Therapy of Gram-Positive Bloodstream Infections
Sign Up to like & getrecommendations! Published in 2018 at "Open Forum Infectious Diseases"
DOI: 10.1093/ofid/ofy210.847
Abstract: Abstract Background Transition from intravenous (IV) to oral (PO) antibiotics is common practice in patients with Gram-positive bloodstream infections (GP-BSI); however, clinical data evaluating IV to PO switch options are lacking. The objective of this… read more here.
Keywords: gram positive; clinical failure; positive bloodstream; oral antibiotics ... See more keywords
1043. Evaluation of Early Clinical Failure Criteria for Gram-Negative Bloodstream Infections
Sign Up to like & getrecommendations! Published in 2018 at "Open Forum Infectious Diseases"
DOI: 10.1093/ofid/ofy210.880
Abstract: Abstract Background Early identification of patients at high risk of morbidity and mortality following Gram-negative bloodstream infections (GN-BSI) based on initial clinical course may prompt adjustments to optimize diagnostic and treatment plans. This retrospective cohort… read more here.
Keywords: early clinical; clinical failure; gram negative; mortality ... See more keywords
Transarterial embolization for postpartum hemorrhage: lessons learned
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DOI: 10.1177/0284185118769691
Abstract: Background Although transarterial embolization (TAE) can powerfully control postpartum hemorrhage (PPH), clinical failure of TAE is not uncommon. Purpose To discover whether any parameters could predict timely clinical failure of TAE, then whether a supplementary… read more here.
Keywords: postpartum hemorrhage; clinical failure; tae; transarterial embolization ... See more keywords
Hip Arthroscopy for Femoroacetabular Impingement Syndrome Performed with Modern Surgical Techniques Provides High Survivorship and Durable Outcome
Sign Up to like & getrecommendations! Published in 2019 at "Orthopaedic Journal of Sports Medicine"
DOI: 10.1177/2325967119s00319
Abstract: Objectives: To analyze predictors of clinical failure as defined by revision hip arthroscopy or conversion to total hip arthroplasty (THA) as well as predictors of inferior outcomes defined as the not reaching Minimally Clinical Important… read more here.
Keywords: pain; pathology; hip arthroscopy; clinical failure ... See more keywords
Ceftriaxone 1 g Versus 2 g Daily for the Treatment of Enterobacterales Bacteremia: A Retrospective Cohort Study
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Pharmacy Technology"
DOI: 10.1177/87551225221121252
Abstract: Background: Ceftriaxone is a commonly used antibiotic for the treatment of susceptible Enterobacterales infections. There is currently limited clinical data on the optimal dose of ceftriaxone for Enterobacterales bacteremia. Objectives: To evaluate the rate of… read more here.
Keywords: versus daily; clinical failure; enterobacterales bacteremia; ceftriaxone versus ... See more keywords
Evaluating Risk Factors for Clinical Failure Among Tigecycline-Treated Patients
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DOI: 10.2147/idr.s496809
Abstract: Purpose Clinical trials have documented that tigecycline has a higher mortality risk than other treatments; it continues to be widely used for various infections in real-world settings, where its associated risk factors for clinical failure… read more here.
Keywords: tigecycline treated; clinical failure; treated patients; risk factors ... See more keywords