Implications of Selection Bias Due to Delayed Study Entry in Clinical Genomic Studies.
Sign Up to like & getrecommendations! Published in 2021 at "JAMA oncology"
DOI: 10.1001/jamaoncol.2021.5153
Abstract: Importance Real-world data sets that combine clinical and genomic data may be subject to left truncation (when potential study participants are not included because they have already passed the milestone of interest at the time… read more here.
Keywords: implications selection; study; clinical genomic; left truncation ... See more keywords
Clinical, genomic, and transcriptomic differences between myelodysplastic syndrome/myeloproliferative neoplasm with ring sideroblasts and thrombocytosis (MDS/MPN‐RS‐T) and myelodysplastic syndrome with ring sideroblasts (MDS‐RS)
Sign Up to like & getrecommendations! Published in 2021 at "American Journal of Hematology"
DOI: 10.1002/ajh.26182
Abstract: REFERENCES 1. Kumar SK, Callander NS, Hillengass J, et al. NCCN guidelines insights: multiple myeloma, version 1.2020. J Natl Compr Canc Netw. 2019;17 (10):1154-1165. 2. Cheson BD, Leoni L. Bendamustine: mechanism of action and clinical… read more here.
Keywords: genomic transcriptomic; ring sideroblasts; multiple myeloma; myelodysplastic syndrome ... See more keywords
Clinical and genomic characterization of mutational signatures across human cancers
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DOI: 10.1002/ijc.34402
Abstract: Mutational signatures, the generic patterns of mutations, are the footprints of both endogenous and exogenous factors that have influenced cancer development. To date, dozens of mutational signatures have been discerned through computational methods. However, the… read more here.
Keywords: cancer; related signature; clinical genomic; mutation ... See more keywords
Clinical and genomic data of sars-cov-2 detected in maternal-fetal interface during the first wave of infection in brazil
Sign Up to like & getrecommendations! Published in 2022 at "Microbes and Infection"
DOI: 10.1016/j.micinf.2022.104949
Abstract: Brazil has the highest SARS-CoV-2 case-fatality rate in pregnant women in the Americas. In this study, clinical and virological findings of five mildly symptomatic pregnant women and their infected fetuses/newborns treated at a referral hospital… read more here.
Keywords: pregnant women; sars cov; genomic data; clinical genomic ... See more keywords
Clinical and genomic analyses of neuroendocrine neoplasms of the breast
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DOI: 10.1038/s41379-021-00965-w
Abstract: Breast neuroendocrine neoplasms (NENs) constitute a rare histologic subtype that includes both neuroendocrine tumors (NETs) and neuroendocrine carcinomas (NECs). In this study, we aimed to gain insight into the clinical and molecular characteristics of NENs… read more here.
Keywords: neoplasms breast; breast; neuroendocrine neoplasms; clinical genomic ... See more keywords
Clinical genomic testing: what matters to key stakeholders?
Sign Up to like & getrecommendations! Published in 2020 at "European Journal of Human Genetics"
DOI: 10.1038/s41431-020-0576-1
Abstract: Beyond a narrow focus on cost and outcomes, robust evidence of what is valued in genomic medicine is scarce. We gathered views on value from key stakeholders (clinical genomic staff, operational genomic staff and community… read more here.
Keywords: testing contexts; key stakeholders; clinical genomic; stakeholders clinical ... See more keywords
Clinical genomics, big data, and electronic medical records: reconciling patient rights with research when privacy and science collide
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Law and the Biosciences"
DOI: 10.1093/jlb/lsw061
Abstract: Abstract Widespread use of medical records for research, without consent, attracts little scrutiny compared to biospecimen research, where concerns about genomic privacy prompted recent federal proposals to mandate consent. This paper explores an important consequence… read more here.
Keywords: research; genomic data; clinical genomics; clinical genomic ... See more keywords
NCOG-50. CLINICAL AND GENOMIC FACTORS ASSOCIATED WITH SEIZURES IN MENINGIOMAS
Sign Up to like & getrecommendations! Published in 2020 at "Neuro-oncology"
DOI: 10.1093/neuonc/noaa215.588
Abstract: Clinical and genomic sequencing data of 394 patients surgically treated for meningioma were reviewed to better understand the relationship between seizures and meningiomas. Correlations of clinical and genomic variables and occurrence of preoperative (PRESZ) and… read more here.
Keywords: presz; atypical histology; seizures meningiomas; clinical genomic ... See more keywords
Availability and funding of clinical genomic sequencing globally
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DOI: 10.1136/bmjgh-2020-004415
Abstract: The emergence of next-generation genomic sequencing (NGS) tests for use in clinical care has generated widespread interest around the globe, but little is known about the availability and funding of these tests worldwide. We examined… read more here.
Keywords: availability; genomic sequencing; funding clinical; clinical genomic ... See more keywords
Abstract SS1-11: Comprehensive analysis of health services, sociodemographic, clinical, and genomic factors driving locally advanced breast cancer mortality via a first-in-kind linkage of SEER-Medicare data with physical tumor samples
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DOI: 10.1158/1538-7445.sabcs20-ss1-11
Abstract: Background: There continues to be an active debate as to the relative contribution of health services, sociodemographic, clinical, and genomic factors in breast cancer disparities. Efforts to understand the contributions of each of these factors… read more here.
Keywords: health services; cancer; breast cancer; clinical genomic ... See more keywords
Classification and Personalized Prognostic Assessment on the Basis of Clinical and Genomic Features in Myelodysplastic Syndromes
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DOI: 10.1200/jco.20.01659
Abstract: PURPOSE Recurrently mutated genes and chromosomal abnormalities have been identified in myelodysplastic syndromes (MDS). We aim to integrate these genomic features into disease classification and prognostication. METHODS We retrospectively enrolled 2,043 patients. Using Bayesian networks… read more here.
Keywords: mds; myelodysplastic syndromes; personalized prognostic; genomic features ... See more keywords