The association of histologic grade with acute graft‐versus‐host disease response and outcomes
Sign Up to like & getrecommendations! Published in 2017 at "American Journal of Hematology"
DOI: 10.1002/ajh.24749
Abstract: Consensus criteria are routinely used to clinically grade acute graft‐versus‐host disease (GVHD). A histologic grading system for acute GVHD is available, but there are limited data on its correlation with clinical grade and hematopoietic cell… read more here.
Keywords: histologic; response; grade; clinical grade ... See more keywords
Clinical grade lentiviral vector purification and quality control requirements.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of separation science"
DOI: 10.1002/jssc.202100937
Abstract: Lentiviral vectors have been proven to be a powerful tool in gene therapies that includes the ability to perform long-term gene editing in both dividing and non-dividing cells. In order to meet the rising demand… read more here.
Keywords: purification; quality; lentiviral vectors; clinical grade ... See more keywords
Optimisation of a potency assay for the assessment of immunomodulative potential of clinical grade multipotent mesenchymal stromal cells
Sign Up to like & getrecommendations! Published in 2017 at "Cytotechnology"
DOI: 10.1007/s10616-017-0186-0
Abstract: Clinical use of multipotent Mesenchymal Stromal Cell (MSC)-based medicinal products requires their production in compliance with Good Manufacturing Practices, thus ensuring that the final drug product meets specifications consistently from batch to batch in terms… read more here.
Keywords: mesenchymal stromal; potency; clinical grade; potential clinical ... See more keywords
Radiosynthesis and First-In-Human PET/MRI Evaluation with Clinical-Grade [18F]FTC-146
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Imaging and Biology"
DOI: 10.1007/s11307-017-1064-z
Abstract: PurposeSigma-1 receptors (S1Rs) play an important role in many neurological disorders. Simultaneous positron emission tomography (PET)/magnetic resonance imaging (MRI) with S1R radioligands may provide valuable information for diagnosing and guiding treatment for these diseases. Our… read more here.
Keywords: 18f ftc; ftc 146; pet mri; clinical grade ... See more keywords
Preparation of clinical-grade WBCs using leukocyte reduction filters.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of immunological methods"
DOI: 10.1016/j.jim.2021.113157
Abstract: OBJECTIVE Our goal was to develop a simpler and less expensive method of obtaining human clinical-grade WBCs using an alternative method to continuous leukapheresis. Our purpose for the WBCs is to arm them with rabbit… read more here.
Keywords: reduction; grade wbcs; wbcs; clinical grade ... See more keywords
Polarized microscope assisted study of collagen fibres in Oral Submucous Fibrosis and their clinicopathologic correlation: An in-vitro study.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of oral biology and craniofacial research"
DOI: 10.1016/j.jobcr.2017.07.001
Abstract: Background The present study was aimed to evaluate and analyze orientation and birefringence pattern of collagen fibers histopathologically in different grades of OSMF using the special stain (Picrosirius red) under polarizing microscope and relate these… read more here.
Keywords: collagen; microscope; grade; study ... See more keywords
First clinical‐grade porcine kidney xenotransplant using a human decedent model
Sign Up to like & getrecommendations! Published in 2022 at "American Journal of Transplantation"
DOI: 10.1111/ajt.16930
Abstract: A radical solution is needed for the organ supply crisis, and the domestic pig is a promising organ source. In preparation for a clinical trial of xenotransplantation, we developed an in vivo pre‐clinical human model… read more here.
Keywords: first clinical; clinical grade; porcine; xenotransplantation ... See more keywords
An optimized method for obtaining clinical‐grade specific cell subpopulations from human umbilical cord‐derived mesenchymal stem cells
Sign Up to like & getrecommendations! Published in 2022 at "Cell Proliferation"
DOI: 10.1111/cpr.13300
Abstract: Mesenchymal stem cells (MSCs) are heterogeneous populations with broad application prospects in cell therapy, and using specific subpopulations of MSCs can enhance their particular capability under certain conditions and achieve better therapeutic effects. However, no… read more here.
Keywords: cell; quality; msc; clinical grade ... See more keywords
Accessing clinical-grade genomic classification data through the ClinGen Data Platform
Sign Up to like & getrecommendations! Published in 2022 at "Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing"
DOI: 10.1142/9789811270611_0048
Abstract: The Clinical Genome Resource (ClinGen) serves as an authoritative resource on the clinical relevance of genes and variants. In order to support our curation activities and to disseminate our findings to the community, we have… read more here.
Keywords: grade genomic; data platform; clingen; clinical grade ... See more keywords
Abstract 487: Safety and functional profiling of clinical grade mesenchymal stem cells derived from bone marrow, adipose tissue and Wharton's jelly for cancer therapy
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Research"
DOI: 10.1158/1538-7445.am2020-487
Abstract: Background: Mesenchymal stem cells (MSCs) have the potential as a drug delivery tool in cancer immunotherapy. We previously demonstrated that MSCs can be used to deliver BCG immunotherapy to the hypoxic core of tumors (#AACR-Abstract-3903).… read more here.
Keywords: safety; clinical grade; mscs; cancer ... See more keywords
Abstract 4704: Characterizing and developing the clinical grade next generation sequencing based gut microbiome assay with the bioinformatics solution
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-4704
Abstract: Background: It has been recognized that gut microbiome has impact on the cancer immunotherapy efficacy and Cancer Microbiome-Immune Axis is reported. Also, it is important to discover and identify clinically translatable predictive biomarker in gut… read more here.
Keywords: kit; bioinformatics solution; clinical grade; gut microbiome ... See more keywords