Clinical implementation of gene panel testing for lysosomal storage diseases
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Genetics & Genomic Medicine"
DOI: 10.1002/mgg3.527
Abstract: The diagnostic workup in patients with a clinical suspicion of lysosomal storage diseases (LSD) is often difficult due to the variability in the clinical phenotype. The gold standard for diagnosis of LSDs consists of enzymatic… read more here.
Keywords: implementation gene; lysosomal storage; clinical implementation; storage diseases ... See more keywords
Clinical implementation of AI technologies will require interpretable AI models.
Sign Up to like & getrecommendations! Published in 2019 at "Medical physics"
DOI: 10.1002/mp.13891
Abstract: Artificial intelligence (AI) technologies have been heavily investigated in recent years in various contexts of science and technology. AI models are known to be powerful tools to help us resolve complex problems even though most… read more here.
Keywords: require interpretable; implementation technologies; interpretable models; clinical implementation ... See more keywords
[The Bárány Classification of vestibular disorders, its clinical implementation and future prospects].
Sign Up to like & getrecommendations! Published in 2020 at "HNO"
DOI: 10.1007/s00106-020-00847-8
Abstract: Vestibular diseases often have no or only nonspecific biomarkers. It is therefore necessary to define these disorders using operational criteria based on patterns of symptoms, i.e., the presence of inclusion and exclusion criteria, similar to… read more here.
Keywords: classification vestibular; future prospects; clinical implementation; vestibular disorders ... See more keywords
Clinical Implementation of Pharmacogenomics for Personalized Precision Medicine: Barriers and Solutions.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of pharmaceutical sciences"
DOI: 10.1016/j.xphs.2017.04.051
Abstract: Clinical implementation of pharmacogenomics (PGx) leads to personalized medicine, which improves the efficacy, safety, and cost-effectiveness of treatments. Although PGx-based research has been conducted for more than a decade, several barriers have slowed down its… read more here.
Keywords: medicine; implementation pharmacogenomics; implementation; barriers solutions ... See more keywords
The clinical implementation of copy number detection in the age of next-generation sequencing
Sign Up to like & getrecommendations! Published in 2018 at "Expert Review of Molecular Diagnostics"
DOI: 10.1080/14737159.2018.1523723
Abstract: ABSTRACT Introduction: The role of copy number variants (CNVs) in disease is now well established. In parallel NGS technologies, such as long-read technologies, there is continual development and data analysis methods continue to be refined.… read more here.
Keywords: copy number; clinical implementation; detection; implementation copy ... See more keywords
Current pharmacogenomic recommendations in chronic respiratory diseases: Is there a biomarker ready for clinical implementation?
Sign Up to like & getrecommendations! Published in 2022 at "Expert Review of Respiratory Medicine"
DOI: 10.1080/17476348.2022.2149496
Abstract: ABSTRACT Introduction The study of genetic variants in response to different drugs has predominated in fields of medicine such as oncology and infectious diseases. In chronic respiratory diseases, the available pharmacogenomic information is scarce but… read more here.
Keywords: pharmacogenomic recommendations; clinical implementation; chronic respiratory; respiratory ... See more keywords
Nanotherapeutics in transplantation: How do we get to clinical implementation?
Sign Up to like & getrecommendations! Published in 2022 at "American Journal of Transplantation"
DOI: 10.1111/ajt.17012
Abstract: Patients undergoing organ transplantation transition from one life‐altering issue (organ dysfunction) to a lifelong commitment—immunosuppression. Regimens of immunosuppressive agents (ISAs) come with significant side effects and comorbidities. Recently, the use of nanoparticles (NPs) as a… read more here.
Keywords: get clinical; transplantation get; clinical implementation; nanotherapeutics transplantation ... See more keywords
Challenges in the Clinical Implementation of a Biopsychosocial Model for Assessment and Management of Orofacial Pain.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of oral rehabilitation"
DOI: 10.1111/joor.12871
Abstract: Distress, suffering, and care-seeking behavior are characteristics of pain-related disease and illness. Pain that transitions from an acute to a chronic phase carries with it the potential of further effects: these include a worsening of… read more here.
Keywords: orofacial pain; biopsychosocial model; clinical implementation; model ... See more keywords
Clinical implementation of a comprehensive targeted amplicon sequencing system for the patients with gastrointestinal cancer as a real world evidence in Japan.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2018.36.4_suppl.329
Abstract: 329Background: Clinical implementation of genome sequencing is recently prevailing in the treatment for cancer. We have launched an in-house clinical sequencing system to perform exhaustive targeted exome sequencing for patients with all types of cancer,… read more here.
Keywords: gastrointestinal cancer; clinical implementation; sequencing system; system patients ... See more keywords
Vascular biomarkers in the prevention of childhood cardiovascular risk: From concept to clinical implementation
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cardiovascular Medicine"
DOI: 10.3389/fcvm.2022.935810
Abstract: Vascular biomarkers allow for non-invasive assessment of vascular structure and function and have been shown to be surrogates for cardiovascular (CV) outcome in adults. They reflect the cumulative risk of a plethora of single CV… read more here.
Keywords: childhood; clinical implementation; risk; vascular biomarkers ... See more keywords
Challenges in Glioblastoma Radiomics and the Path to Clinical Implementation
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14163897
Abstract: Simple Summary Glioblastoma (GBM) is a cancer with poor prognosis, its 5-year survival expectation is approximately 5%. Advances in oncologic treatment techniques have not led to significant improvements in survival outcomes for GBM patients. Part… read more here.
Keywords: glioblastoma radiomics; implementation; gbm patients; clinical implementation ... See more keywords