Clinical implications of SRSF2 mutations in AML patients undergoing allogeneic stem cell transplantation
Sign Up to like & getrecommendations! Published in 2021 at "American Journal of Hematology"
DOI: 10.1002/ajh.26298
Abstract: The SRSF2 mutations are frequently found in acute myeloid leukemia (AML) and mostly affect the P95 residue. Mutations in this splicing factor mediate abnormal splicing associated with exon skipping events, including EZH2 as a crucial… read more here.
Keywords: aml patients; hsct; clinical implications; implications srsf2 ... See more keywords
Spectrum of EGFR aberrations and potential clinical implications: insights from integrative pan‐cancer analysis
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Communications"
DOI: 10.1002/cac2.12005
Abstract: Human epidermal growth factor receptor (EGFR) is an oncogenic gene and one of top targets of precision therapy in lung cancer with EGFR mutations. Although there are many reports for some individual cancers, comprehensive profiling… read more here.
Keywords: egfr aberrations; clinical implications; potential clinical; aberrations potential ... See more keywords
Clinical implications and molecular features of tertiary lymphoid structures in stage I lung adenocarcinoma
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Medicine"
DOI: 10.1002/cam4.5731
Abstract: We investigated the clinical implications and molecular features of TLS in stage I lung adenocarcinoma (LUAD). read more here.
Keywords: implications molecular; lung adenocarcinoma; clinical implications; stage lung ... See more keywords
The clinical implications of immunogenomics in colorectal cancer: A path for precision medicine
Sign Up to like & getrecommendations! Published in 2018 at "Cancer"
DOI: 10.1002/cncr.31214
Abstract: Colorectal cancer (CRC) remains the third most common malignancy and the second‐leading cause of cancer‐related deaths in the United States. Large multi‐omic databases, such as The Cancer Genome Atlas and the International Colorectal Cancer Subtyping… read more here.
Keywords: medicine; immunogenomics colorectal; implications immunogenomics; colorectal cancer ... See more keywords
Preeclampsia and the Kidney: Pathophysiology and Clinical Implications.
Sign Up to like & getrecommendations! Published in 2023 at "Comprehensive Physiology"
DOI: 10.1002/cphy.c210051
Abstract: Preeclampsia and other hypertensive disorders of pregnancy are major contributors to maternal morbidity and mortality worldwide. This group of disorders includes chronic hypertension, gestational hypertension, preeclampsia, preeclampsia superimposed on chronic hypertension, and eclampsia. The body… read more here.
Keywords: clinical implications; implications preeclampsia; pathophysiology; kidney ... See more keywords
Clinical Implications of Complex Pharmacokinetics for Daratumumab Dose Regimen in Patients With Relapsed/Refractory Multiple Myeloma
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DOI: 10.1002/cpt.577
Abstract: New therapeutic strategies are urgently needed to improve clinical outcomes in patients with multiple myeloma (MM). Daratumumab is a first‐in‐class, CD38 human immunoglobulin G1κ monoclonal antibody approved for treatment of relapsed or refractory MM. Identification… read more here.
Keywords: relapsed refractory; clinical implications; multiple myeloma; dose regimen ... See more keywords
CLINICAL IMPLICATIONS OF CYTOPENIAS BEYOND DAY 30 AFTER AXI‐CEL THERAPY IN PATIENTS WITH RELAPSED/REFRACTORY LARGE B‐CELL LYMPHOMA
Sign Up to like & getrecommendations! Published in 2019 at "Hematological Oncology"
DOI: 10.1002/hon.120_2630
Abstract: ment-related event (hepatic encephalopathy). CRS/IRR was reported in 25% of pts, with only 1 Gr 3 event. Most common CRS symptoms were pyrexia (86%), chills (38%), and tachycardia and headache (14% each). There were no… read more here.
Keywords: implications cytopenias; clinical implications; beyond day; day ... See more keywords
Functional and clinical implications of genetic structure in 1686 Italian exomes
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DOI: 10.1002/humu.24156
Abstract: To reconstruct the phenotypical and clinical implications of the Italian genetic structure, we thoroughly analyzed a whole‐exome sequencing data set comprised of 1686 healthy Italian individuals. We found six previously unreported variants with remarkable frequency… read more here.
Keywords: genetic structure; clinical implications; functional clinical; data set ... See more keywords
Anti-diabetic drugs and sarcopenia: emerging links, mechanistic insights, and clinical implications.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of cachexia, sarcopenia and muscle"
DOI: 10.1002/jcsm.12838
Abstract: Sarcopenia, characterized by loss of skeletal muscle mass, quality, and strength, has become a common hallmark of ageing and many chronic diseases. Diabetes mellitus patients have a higher prevalence of sarcopenia, which greatly aggravates the… read more here.
Keywords: sarcopenia; diabetic drugs; clinical implications; muscle mass ... See more keywords
Possible clinical implications of the structural variations between the tympanic membrane quadrants
Sign Up to like & getrecommendations! Published in 2022 at "Laryngoscope Investigative Otolaryngology"
DOI: 10.1002/lio2.861
Abstract: Retraction pockets and marginal perforations of the pars tensa of the tympanic membrane (TM) are most commonly found at superior posterior quadrant (SPQ). The patulous Eustachian tube tends to manifest in the same quadrant. Variation… read more here.
Keywords: membrane; implications structural; clinical implications; structural variations ... See more keywords
Prevalence and clinical implications of germline mutations among Jordanian patients with ovarian cancer. The Jordanian exploratory cancer genetics (Jo‐ECAG) ovarian study
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Genetics & Genomic Medicine"
DOI: 10.1002/mgg3.2125
Abstract: Ovarian cancer is one of the most common gynecological malignancies. Due to the absence of effective screening methods, ovarian cancer is usually diagnosed at late stages. Patients with pathogenic and likely‐pathogenic germline variants (PGVs) in… read more here.
Keywords: clinical implications; ovarian cancer; prevalence clinical; cancer ... See more keywords