Clinical Importance of Clonal Hematopoiesis in Metastatic Gastrointestinal Tract Cancers
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DOI: 10.1001/jamanetworkopen.2022.54221
Abstract: Key Points Question To what extent is clonal hematopoiesis (CH) associated with treatment response and toxicity among patients with metastatic cancer who receive chemotherapy or immune checkpoint blockade? Findings In this cohort study of 633… read more here.
Keywords: metastatic gastrointestinal; hematopoiesis metastatic; importance clonal; clinical importance ... See more keywords
Assessment of Risk Factors and Clinical Importance of Enlarged Perivascular Spaces by Whole-Brain Investigation in the Multi-Ethnic Study of Atherosclerosis
Sign Up to like & getrecommendations! Published in 2023 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2023.9196
Abstract: Key Points Question What is the clinical importance of enlarged perivascular spaces detected on brain magnetic resonance imaging? Findings This cross-sectional study was conducted in a multiethnic sample of 1026 individuals living in the community.… read more here.
Keywords: enlarged perivascular; perivascular spaces; brain; clinical importance ... See more keywords
The clinical importance of CD4+CD7− in human diseases
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.27099
Abstract: The CD7 antigen is a member of the immunoglobulin superfamily that expresses on the surface of all thymocytes, a majority of mature T cells, and also natural killer cells. Interestingly, under physiological and different pathological… read more here.
Keywords: clinical importance; cd4 cd7; importance cd4; cd7 ... See more keywords
Applying the thresholds for clinical importance for fourteen key domains of the EORTC QLQ-C30: a latent class analysis of cancer survivors
Sign Up to like & getrecommendations! Published in 2021 at "Supportive Care in Cancer"
DOI: 10.1007/s00520-021-06292-9
Abstract: A person’s quality of life is impacted from the beginning of their oncology experience. One of the most common tools to measure quality of life is the EORTC QLQ-C30. The absolute scores it produces can… read more here.
Keywords: cancer; cancer survivors; clinical impact; clinical importance ... See more keywords
An evidence rating service provided valid correlates of the clinical importance of medical articles and journals.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of clinical epidemiology"
DOI: 10.1016/j.jclinepi.2019.01.010
Abstract: OBJECTIVES The objective of this study was to determine reliability and validity of McMaster PLUS measures of scientific merit and clinical importance of articles in medical journals. STUDY DESIGN AND SETTING Analytic survey of peer-reviewed… read more here.
Keywords: clinical importance; importance; importance medical; evidence rating ... See more keywords
The fragility of trial results involves more than statistical significance alone.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of clinical epidemiology"
DOI: 10.1016/j.jclinepi.2020.02.011
Abstract: OBJECTIVES The fragility of clinical trial findings has been previously defined as the number of changes in outcomes that are required to change their statistical significance. We show that reliance on statistical significance alone provides… read more here.
Keywords: statistical significance; clinical importance; trial results; significance alone ... See more keywords
Clinical Importance of Tumor Rupture in Gastrointestinal Stromal Tumor.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of digestive diseases"
DOI: 10.1111/1751-2980.13190
Abstract: Risk factors of gastrointestinal stromal tumors (GISTs) include tumor size, location, mitosis, and tumor rupture. Although the first three are commonly recognized as independent prognostic factors, tumor rupture is not a consistent finding. Indeed, tumor… read more here.
Keywords: definition; tumor rupture; clinical importance; tumor ... See more keywords
Clinical importance of molecular markers of adult diffuse glioma
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DOI: 10.1136/practneurol-2018-002116
Abstract: In 2016, the WHO incorporated molecular markers, in addition to histology, into the diagnostic classification of central nervous system (CNS) tumours. This improves diagnostic accuracy and prognostication: oligo-astrocytoma no longer exists as a clinical entity;… read more here.
Keywords: markers adult; clinical importance; prognosis; adult diffuse ... See more keywords
Clinical Importance of Wnt5a in the Pathogenesis of Colorectal Cancer
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DOI: 10.1155/2021/3136508
Abstract: Wnt5a is one of the potent signaling molecules that initiates responses involved in cancer through activation of both canonical and noncanonical signaling cascades. Wnt5a both directly and indirectly triggers cancer-associated signaling pathways based on the… read more here.
Keywords: clinical importance; colorectal cancer; pathogenesis; wnt5a ... See more keywords
Abstract 13148: Clinical Importance of Left Atrial Infiltration in Cardiac Transthyretin Amyloidosis
Sign Up to like & getrecommendations! Published in 2020 at "Circulation"
DOI: 10.1161/circ.142.suppl_3.13148
Abstract: Introduction: The clinical significance of left atrial (LA) involvement and dysfunction in ATTR amyloidosis cardiomyopathy (ATTR-CM) has not been characterized. We sought to study: 1) LA pathology ... read more here.
Keywords: left atrial; 13148 clinical; abstract 13148; importance left ... See more keywords
Clinical Importance of Potential Genetic Determinants Affecting Propofol Pharmacokinetics and Pharmacodynamics
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Medicine"
DOI: 10.3389/fmed.2022.809393
Abstract: Interindividual variability in response to drugs used in anesthesia has long been considered the rule, not the exception. It is important to mention that in anesthesiology, the variability in response to drugs is multifactorial, i.e.,… read more here.
Keywords: pharmacokinetics pharmacodynamics; medicine; clinical importance; importance potential ... See more keywords