Discovery of 2‐phenylquinazolines as potent Mycobacterium avium efflux pump inhibitors able to synergize with clarithromycin against clinical isolate
Sign Up to like & getrecommendations! Published in 2024 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202400296
Abstract: Nontuberculous mycobacteria (NTM), which include the Mycobacterium avium complex, are classified as difficult‐to‐treat pathogens due to their ability to quickly develop drug resistance against the most common antibiotics used to treat NTM infections. The overexpression… read more here.
Keywords: clinical isolate; avium; clarithromycin; mycobacterium avium ... See more keywords
Challenges of Francisella classification exemplified by an atypical clinical isolate.
Sign Up to like & getrecommendations! Published in 2018 at "Diagnostic microbiology and infectious disease"
DOI: 10.1016/j.diagmicrobio.2017.11.023
Abstract: The accumulation of sequenced Francisella strains has made it increasingly apparent that the 16S rRNA gene alone is not enough to stratify the Francisella genus into precise and clinically useful classifications. Continued whole-genome sequencing of… read more here.
Keywords: francisella; clinical isolate; challenges francisella; francisella classification ... See more keywords
Clinical isolate characteristics and demographics of patients with C.jejuni and C.coli infections in Northern Israel, 2015–2021
Sign Up to like & getrecommendations! Published in 2024 at "Epidemiology and Infection"
DOI: 10.1017/s0950268823002005
Abstract: Abstract C.coli is a significant cause of foodborne gastroenteritis worldwide, with the majority of cases attributed to C.jejuni. Although most clinical laboratories do not typically conduct antimicrobial susceptibility testing for C.coli, the rise in resistant… read more here.
Keywords: northern israel; isolate characteristics; infections northern; clinical isolate ... See more keywords
Ciprofloxacin-Tethered 1,2,3-Triazole Conjugates: New Quinolone Family Compounds to Upgrade Our Antiquated Approach against Bacterial Infections
Sign Up to like & getrecommendations! Published in 2022 at "ACS Omega"
DOI: 10.1021/acsomega.1c05303.s001
Abstract: A newer ciprofloxacin series containing 1,2,3-triazole conjugates of ciprofloxacin was designed, synthesized, and well characterized using modern analytical techniques by reacting diversified anilines with ciprofloxacin obtained from ciprofloxacin hydrochloride. The newer conjugates were evaluated for… read more here.
Keywords: compound; ciprofloxacin tethered; clinical isolate; typhi clinical ... See more keywords
Synthesis of ciprofloxacin-linked 1,2,3-triazole conjugates as potent antibacterial agents using click chemistry: exploring their function as DNA gyrase inhibitors via in silico- and in vitro-based studies
Sign Up to like & getrecommendations! Published in 2024 at "RSC Advances"
DOI: 10.1039/d4ra01332h
Abstract: The antibacterial efficacy of some newly developed C-3 carboxylic group-containing ciprofloxacin-linked 1,2,3-triazole conjugates was studied. Twenty-one compounds from three different series of triazoles were synthesized using click chemistry and evaluated for their antibacterial activity against… read more here.
Keywords: clinical isolate; chemistry; ciprofloxacin; dna gyrase ... See more keywords
Complete genome identified of clinical isolate Prototheca.
Sign Up to like & getrecommendations! Published in 2024 at "Journal of medical microbiology"
DOI: 10.1099/jmm.0.001914
Abstract: Introduction. Prototheca is an opportunistic pathogen that can infect both humans and animals, of which Prototheca wickerhamii (P. wickerhamii) being the most significant pathogenic green algae.Gap statement. The incidence of human diseases caused by Prototheca… read more here.
Keywords: analysis; genome; clinical isolate; inpu strain ... See more keywords
Establishment and Characterization of an HBV Viral Spread and Infectious System following Long-Term Passage of an HBV Clinical Isolate in the Primary Human Hepatocyte and Fibroblast Coculture System
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Virology"
DOI: 10.1128/jvi.00849-22
Abstract: The existing cell culture-based methods to study HBV have limitations and do not allow for viral long-term passage. In this study, an HBV genotype A clinical isolate was subjected to multiple rounds of UV treatment… read more here.
Keywords: long term; system; clinical isolate; passage ... See more keywords
hapE and hmg1 Mutations Are Drivers of cyp51A-Independent Pan-Triazole Resistance in an Aspergillus fumigatus Clinical Isolate
Sign Up to like & getrecommendations! Published in 2023 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.05188-22
Abstract: Triazole resistance is an important cause of treatment failure and high mortality rates for A. fumigatus human infections. Although Cyp51A-associated mutations are frequently identified as the cause of A. fumigatus triazole resistance, they do not… read more here.
Keywords: clinical isolate; hape hmg1; resistance; triazole resistance ... See more keywords
Proteomic analysis of the colistin-resistant E. coli clinical isolate: Explorations of the resistome.
Sign Up to like & getrecommendations! Published in 2021 at "Protein and peptide letters"
DOI: 10.2174/0929866528666211129095001
Abstract: BACKGROUND Antimicrobial resistance is a worldwide problem after the emergence of colistin resistance since it was the last option left to treat carbapenemase-resistant bacterial infections. The mcr gene and its variants are one of the… read more here.
Keywords: coli clinical; resistance; clinical isolate; colistin ... See more keywords
Characterization of Extracellular Vesicles Secreted by a Clinical Isolate of Naegleria fowleri and Identification of Immunogenic Components within Their Protein Cargo
Sign Up to like & getrecommendations! Published in 2022 at "Biology"
DOI: 10.3390/biology11070983
Abstract: Simple Summary Extracellular vesicles are vesicles produced by cells and organisms, capable of developing different functions. In this sense, these vesicles have been involved in communication, in the production of damage during an infection and… read more here.
Keywords: naegleria fowleri; extracellular vesicles; clinical isolate; vesicles secreted ... See more keywords