Clinical and laboratory features of autoimmune hemolytic anemia associated with immune checkpoint inhibitors
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DOI: 10.1002/ajh.25448
Abstract: Immune checkpoint inhibitors (ICPis) are a novel class of immunotherapeutic agents that have revolutionized the treatment of cancer; however, these drugs can also cause a unique spectrum of autoimmune toxicity. Autoimmune hemolytic anemia (AIHA) is… read more here.
Keywords: immune checkpoint; checkpoint inhibitors; autoimmune hemolytic; hemolytic anemia ... See more keywords
Peripheral blood clinical laboratory variables associated with outcomes following combination nivolumab and ipilimumab immunotherapy in melanoma
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DOI: 10.1002/cam4.1356
Abstract: Both the combination of nivolumab + ipilimumab and single‐agent anti‐PD‐1 immunotherapy have demonstrated survival benefit for patients with advanced melanoma. As the combination has a high rate of serious side effects, further analyses in randomized… read more here.
Keywords: combination; immunotherapy; combination nivolumab; clinical laboratory ... See more keywords
Mastocytosis presenting with mast cell-mediator release-associated symptoms elicited by cyclo oxygenase inhibitors: prevalence, clinical, and laboratory features.
Sign Up to like & getrecommendations! Published in 2022 at "Clinical and translational allergy"
DOI: 10.1002/clt2.12132
Abstract: BACKGROUND Nonsteroidal anti-inflammatory drugs (NSAIDs) are frequently avoided in mastocytosis, because of a potential increased risk for drug hypersensitivity reactions (DHRs) due to inhibition of cyclo-oxygenase (COX), subsequent depletion of prostaglandin E2 and release of… read more here.
Keywords: clinical laboratory; release; nsaids coxi; mediator ... See more keywords
Common and rare myocilin variants: Predicting glaucoma pathogenicity based on genetics, clinical, and laboratory misfolding data
Sign Up to like & getrecommendations! Published in 2021 at "Human Mutation"
DOI: 10.1002/humu.24238
Abstract: Rare variants of the olfactomedin domain of myocilin are considered causative for inherited, early‐onset open‐angle glaucoma, with a misfolding toxic gain‐of‐function pathogenic mechanism detailed by 20 years of laboratory research. Myocilin variants are documented in… read more here.
Keywords: myocilin; genetics; glaucoma; pathogenicity ... See more keywords
Lean six sigma methodologies improve clinical laboratory efficiency and reduce turnaround times
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DOI: 10.1002/jcla.22180
Abstract: Organizing work flow is a major task of laboratory management. Recently, clinical laboratories have started to adopt methodologies such as Lean Six Sigma and some successful implementations have been reported. This study used Lean Six… read more here.
Keywords: lean six; clinical laboratory; six sigma; turnaround ... See more keywords
Novel classifiers with clinical laboratory parameters for early detection of osteosarcoma
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.23189
Abstract: Osteosarcoma (OS) is one of the most common malignant bone tumors. It is essential to explore early diagnostic indicators with high sensitivity and specificity due to the rapid progression and metastasis of OS and the… read more here.
Keywords: classifiers clinical; parameters early; laboratory; laboratory parameters ... See more keywords
The importance of using routine laboratory tests in the diagnosis and prognosis of patients with coronavirus disease 2019: Shedding light on clinical laboratory data in COVID‐19
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.24713
Abstract: Novel coronavirus (COVID‐19) pandemic has become a global concern and requires early detection, isolation, and treatment. Our purpose is to find some beneficial information by analyzing the COVID‐19 laboratory data to provide guidance for clinical… read more here.
Keywords: laboratory; laboratory data; importance using; using routine ... See more keywords
Clinical and laboratory detection of nonpolio enteroviruses among different age groups of aseptic meningitis patients in Alexandria, Egypt
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Medical Virology"
DOI: 10.1002/jmv.26480
Abstract: Viral meningitis is the most common type of meningitis. Worldwide, nonpolio enteroviruses (NPEVs) account for 23%–60% of all cases of viral meningitis. We aimed to detect NPEV among aseptic meningitis cases using reverse transcription‐polymerase chain… read more here.
Keywords: meningitis; laboratory detection; nonpolio enteroviruses; clinical laboratory ... See more keywords
Clinical and laboratory features and factors predicting disease severity in pediatric patients with hemorrhagic fever with renal syndrome caused by Hantaan virus
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medical Virology"
DOI: 10.1002/jmv.28339
Abstract: The clinical features and factors associated with disease severity in children with hemorrhagic fever with renal syndrome (HFRS) have not been well characterized. This study analyzed the clinical and laboratory factors associated with disease severity… read more here.
Keywords: clinical laboratory; disease; disease severity; predicting disease ... See more keywords
Do clinical and laboratory parameters predict thiopurine metabolism and clinical outcome in patients with inflammatory bowel diseases?
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Clinical Pharmacology"
DOI: 10.1007/s00228-018-02616-7
Abstract: PurposeThe thiopurines azathioprine and 6-mercaptopurine are frequently used for remission maintenance in patients with inflammatory bowel diseases. However, there are therapy failures, and it is unclear whether clinical and laboratory parameters can be used to… read more here.
Keywords: patients inflammatory; inflammatory bowel; bowel diseases; laboratory ... See more keywords
Sarcopenia in systemic sclerosis: the impact of nutritional, clinical, and laboratory features
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DOI: 10.1007/s00296-019-04401-w
Abstract: We evaluated the presence of sarcopenia in a population of systemic sclerosis (SSc) patients, with respect to nutritional, clinical, and laboratory features. A total of 62 patients who met the ACR/EULAR 2013 classification criteria were… read more here.
Keywords: sarcopenia; systemic sclerosis; nutritional clinical; laboratory features ... See more keywords