Evaluating the clinical and mechanistic effects of eplerenone and amiloride monotherapy, and combination therapy with cinacalcet, in primary hyperparathyroidism: A placebo‐controlled randomized trial
Sign Up to like & getrecommendations! Published in 2022 at "Clinical Endocrinology"
DOI: 10.1111/cen.14840
Abstract: Human physiology and epidemiology studies have demonstrated complex interactions between the renin–angiotensin–aldosterone system, parathyroid hormone and calcium homeostasis. Several of these studies have suggested that aldosterone inhibition may lower parathyroid hormone (PTH) levels. The objective… read more here.
Keywords: clinical mechanistic; primary hyperparathyroidism; therapy; placebo ... See more keywords
Endocrine disruptor chemicals as obesogen and diabetogen: Clinical and mechanistic evidence
Sign Up to like & getrecommendations! Published in 2022 at "World Journal of Clinical Cases"
DOI: 10.12998/wjcc.v10.i31.11226
Abstract: Obesity is becoming an inevitable pandemic all over the world. The World Obesity Federation predicts in the 2022 World Obesity Atlas that one billion people worldwide, including 1 in 5 women and 1 in 7… read more here.
Keywords: world; clinical mechanistic; obesogen diabetogen; obesity ... See more keywords
Clinical and Mechanistic Review of Amiodarone-Associated Optic Neuropathy
Sign Up to like & getrecommendations! Published in 2022 at "Biomolecules"
DOI: 10.3390/biom12091298
Abstract: Amiodarone-associated optic neuropathy (AAON) is a complex clinical diagnosis, requiring distinction from non-arteritic ischemic optic neuropathy (NAION) due to a shared at-risk patient population. Diagnosis of AAON is complicated by a varied clinical presentation and… read more here.
Keywords: optic neuropathy; clinical mechanistic; mechanistic review; amiodarone associated ... See more keywords
Clinical and Mechanistic Implications of R-Loops in Human Leukemias
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24065966
Abstract: Genetic mutations or environmental agents are major contributors to leukemia and are associated with genomic instability. R-loops are three-stranded nucleic acid structures consisting of an RNA–DNA hybrid and a non-template single-stranded DNA. These structures regulate… read more here.
Keywords: genomic instability; loops human; clinical mechanistic; human leukemias ... See more keywords