2563. Clinical Metagenomic Next-Generation Sequencing for Diagnosis of Meningitis and Encephalitis
Sign Up to like & getrecommendations! Published in 2018 at "Open Forum Infectious Diseases"
DOI: 10.1093/ofid/ofy209.171
Abstract: Abstract Background Metagenomic next-generation sequencing (mNGS) of CSF can identify nearly all pathogens in a single test. We previously validated a CSF mNGS assay in a licensed clinical laboratory. To date, the utility of mNGS… read more here.
Keywords: diagnosis; metagenomic next; clinical metagenomic; encephalitis ... See more keywords
Clinical metagenomic sequencing for rapid diagnosis of neonatal meningitis caused by Ureaplasma parvum
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DOI: 10.1097/md.0000000000028662
Abstract: Abstract Introduction: It is challenging to obtain favorable results through conventional diagnostic testing for Ureaplasma parvum (UP), a conditional pathogen, because of the atypical clinical phenotype of UP meningitis. Patient concerns and diagnosis: Herein, we… read more here.
Keywords: clinical metagenomic; meningitis; diagnosis; ureaplasma parvum ... See more keywords
Background Filtering of Clinical Metagenomic Sequencing with a Library Concentration-Normalized Model
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DOI: 10.1128/spectrum.01779-22
Abstract: Most of the existing methods to remove wet-lab contamination rely on large-scale observational microbiome studies and may not be applicable to clinical mNGS testing in individual cases. In clinical settings, only a handful of samples… read more here.
Keywords: clinical metagenomic; clinical settings; model; metagenomic sequencing ... See more keywords