Detection of circulating highly expanded T-cell clones in at-risk individuals for rheumatoid arthritis before the clinical onset of the disease.
Sign Up to like & getrecommendations! Published in 2020 at "Rheumatology"
DOI: 10.1093/rheumatology/keaa790
Abstract: OBJECTIVES To quantitatively profile the T-cell repertoire in the peripheral blood of individuals genetically at risk for RA, namely first-degree relatives of RA patients (RA-FDR) at different phases of disease development. METHODS Next-generation sequencing of… read more here.
Keywords: highly expanded; clinical onset; cell clones; disease ... See more keywords
Small-area distribution of multiple sclerosis incidence in western France: in search of environmental triggers
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Health Geographics"
DOI: 10.1186/s12942-017-0108-6
Abstract: BackgroundDespite intensive research over several decades, the etiology of multiple sclerosis (MS) remains poorly understood, although environmental factors are supposedly implicated. Our goal was to identify spatial clusters of MS incident cases at the small-area… read more here.
Keywords: incidence; clinical onset; multiple sclerosis; small area ... See more keywords
Searching for neurodegeneration in multiple sclerosis at clinical onset: Diagnostic value of biomarkers
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DOI: 10.1371/journal.pone.0194828
Abstract: Background Neurodegeneration occurs during the early stages of multiple sclerosis. It is an essential, devastating part of the pathophysiology. Tools for measuring the degree of neurodegeneration could improve diagnostics and patient characterization. Objective This study… read more here.
Keywords: sclerosis; clinical onset; neurodegeneration; multiple sclerosis ... See more keywords