The use of a modified Delphi technique to develop a critical appraisal tool for clinical pharmacokinetic studies
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DOI: 10.1007/s11096-022-01390-y
Abstract: Critical appraisal aids in assessing the quality of scientific literature, which is central to the practice of evidence-based medicine. Several tools and guidelines are available for critiquing and assessing the quality of specific study types.… read more here.
Keywords: tool; pharmacokinetic studies; critical appraisal; quality ... See more keywords
Clinical Pharmacokinetic and Pharmacodynamic Profile of Riociguat
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DOI: 10.1007/s40262-017-0604-7
Abstract: Oral riociguat is a soluble guanylate cyclase (sGC) stimulator that targets the nitric oxide (NO)–sGC–cyclic guanosine monophosphate pathway with a dual mode of action: directly by stimulating sGC, and indirectly by increasing the sensitivity of… read more here.
Keywords: pharmacodynamic profile; profile riociguat; sgc; pharmacokinetic pharmacodynamic ... See more keywords
A high‐performance liquid chromatography‐tandem mass spectrometry method for the determination of lifrafenib, a novel RAF kinase and EGFR inhibitor, in human plasma and urine and its application in clinical pharmacokinetic study
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DOI: 10.1016/j.jpba.2018.12.038
Abstract: &NA; Lifirafenib (BGB‐283), a dual inhibitor trageting BRAF kinase and EGFR, showed favorable efficacy and safety in treating patients with different cancer types harboring mutations in BRAF, KRAS and NRAS. In order to support the… read more here.
Keywords: clinical pharmacokinetic; plasma; pharmacokinetic study; plasma urine ... See more keywords
Tutorial: Statistical analysis and reporting of clinical pharmacokinetic studies
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DOI: 10.1111/cts.13305
Abstract: Pharmacokinetics is the cornerstone of understanding drug absorption, distribution, metabolism, and elimination. It is also the key to describing variability in drug response caused by drug‐drug interactions (DDIs), pharmacogenetics, impaired kidney and liver function, etc.… read more here.
Keywords: pharmacokinetic studies; reporting clinical; statistical analysis; drug ... See more keywords
Clinical pharmacokinetic interactions between lamotrigine and hormonal contraceptives in bipolar I disorder
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DOI: 10.1111/pcn.12512
Abstract: Lamotrigine (LTG) is prescribed for bipolar disorder and epilepsy. Oral contraceptives (OCs) containing estrogen may reciprocally decrease the concentration of LTG. We present a case of a female patient with bipolar I disorder with prolonged… read more here.
Keywords: disorder; interactions lamotrigine; lamotrigine hormonal; bipolar disorder ... See more keywords