Effects of Intrinsic Factors on the Clinical Pharmacokinetics of Vortioxetine
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DOI: 10.1002/cpdd.577
Abstract: Vortioxetine is an antidepressant agent with multimodal activity that is approved for the treatment of major depressive disorder at doses of 5 to 20 mg once daily. Vortioxetine is a medium‐clearance drug that undergoes extensive… read more here.
Keywords: clinical pharmacokinetics; pharmacokinetics vortioxetine; factors clinical; intrinsic factors ... See more keywords
Review of the Clinical Pharmacokinetics and Pharmacodynamics of Alemtuzumab and Its Use in Kidney Transplantation
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DOI: 10.1007/s40262-017-0573-x
Abstract: Alemtuzumab is a humanized monoclonal antibody against CD52 and causes depletion of T and B lymphocytes, monocytes, and NK cells. Alemtuzumab is registered for the treatment of multiple sclerosis (MS) and is also used in… read more here.
Keywords: clinical pharmacokinetics; rejection; kidney transplantation; pharmacokinetics pharmacodynamics ... See more keywords
Clinical Pharmacokinetics and Pharmacodynamics of Evolocumab, a PCSK9 Inhibitor
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DOI: 10.1007/s40262-017-0620-7
Abstract: Proprotein convertase subtilisin/kexin type 9 (PCSK9) increases plasma low-density lipoprotein cholesterol (LDL-C) by decreasing expression of the LDL receptor on hepatic cells. Evolocumab is a human monoclonal immunoglobulin G2 that binds specifically to human PCSK9… read more here.
Keywords: clinical pharmacokinetics; evolocumab pcsk9; ldl; pharmacokinetics pharmacodynamics ... See more keywords
Clinical Pharmacokinetics and Pharmacodynamics of Telavancin Compared with the Other Glycopeptides
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DOI: 10.1007/s40262-017-0623-4
Abstract: Telavancin was discovered by modifying the chemical structure of vancomycin and belongs to the group of lipoglycopeptides. It employs its antimicrobial potential through two distinct mechanisms of action: inhibition of bacterial cell wall synthesis and… read more here.
Keywords: clinical pharmacokinetics; telavancin; plasma; soft tissue ... See more keywords
Clinical Pharmacokinetics and Pharmacodynamics of Infliximab in the Treatment of Inflammatory Bowel Disease
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DOI: 10.1007/s40262-017-0627-0
Abstract: Infliximab was the first monoclonal antibody to be approved for the treatment of pediatric and adult patients with moderately to severely active Crohn’s disease (CD) and ulcerative colitis (UC). It has been shown to induce… read more here.
Keywords: clinical pharmacokinetics; bowel disease; inflammatory bowel; treatment ... See more keywords
Clinical Pharmacokinetics and Pharmacodynamics of Propofol
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DOI: 10.1007/s40262-018-0672-3
Abstract: Propofol is an intravenous hypnotic drug that is used for induction and maintenance of sedation and general anaesthesia. It exerts its effects through potentiation of the inhibitory neurotransmitter γ-aminobutyric acid (GABA) at the GABAA receptor,… read more here.
Keywords: clinical pharmacokinetics; pharmacodynamics propofol; drug; effect ... See more keywords
Clinical Pharmacokinetics and Impact of Hematocrit on Monitoring and Dosing of Tacrolimus Early After Heart and Lung Transplantation
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DOI: 10.1007/s40262-019-00846-1
Abstract: The calcineurin inhibitor tacrolimus is an effective immunosuppressant and is extensively used in solid organ transplantation. In the first week after heart and lung transplantation, tacrolimus dosing is difficult due to considerable physiological changes because… read more here.
Keywords: heart lung; clinical pharmacokinetics; transplantation; lung transplantation ... See more keywords
Clinical Pharmacokinetics and Pharmacodynamics of the Cyclin-Dependent Kinase 4 and 6 Inhibitors Palbociclib, Ribociclib, and Abemaciclib
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DOI: 10.1007/s40262-020-00930-x
Abstract: Palbociclib, ribociclib, and abemaciclib are inhibitors of the cyclin-dependent kinases 4 and 6 approved for the treatment of locally advanced or metastatic breast cancer. In this review, we provide an overview of the available clinical… read more here.
Keywords: clinical pharmacokinetics; cyclin dependent; palbociclib ribociclib; ribociclib abemaciclib ... See more keywords
Clinical Pharmacokinetics and Pharmacodynamics of Selumetinib
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DOI: 10.1007/s40262-020-00967-y
Abstract: Selumetinib, a highly specific mitogen-activated protein kinase 1/2 inhibitor, is approved for children older than 2 years of age with neurofibromatosis 1 who have inoperable plexiform neurofibromas. By selectively binding to mitogen-activated protein kinase 1/2… read more here.
Keywords: selumetinib; clinical pharmacokinetics; activated protein; protein kinase ... See more keywords
Clinical Pharmacokinetics and Pharmacodynamics of Lefamulin
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DOI: 10.1007/s40262-021-01056-4
Abstract: Lefamulin (Xenleta) has been approved by the US FDA for the treatment of community-acquired bacterial pneumonia (CABP). It may be taken intravenously or orally and has activity against a broad range of pulmonary pathogens, including… read more here.
Keywords: clinical pharmacokinetics; treatment; pharmacodynamics lefamulin; pharmacokinetics pharmacodynamics ... See more keywords
Transporter-Mediated Disposition, Clinical Pharmacokinetics and Cholestatic Potential of Glyburide and Its Primary Active Metabolites
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DOI: 10.1124/dmd.116.074815
Abstract: Glyburide is widely used for the treatment of type 2 diabetes. We studied the mechanisms involved in the disposition of glyburide and its pharmacologically active hydroxy metabolites M1 and M2b and evaluated their clinical pharmacokinetics… read more here.
Keywords: clinical pharmacokinetics; disposition; transporter mediated; active metabolites ... See more keywords