Clinical Pharmacology of Insulin Aspart Biosimilar GP40071: Pharmacokinetic/Pharmacodynamic Comparability in Hyperinsulinemic Euglycemic Clamp Procedure
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DOI: 10.1002/cpdd.1084
Abstract: Insulin aspart is a short‐acting insulin analogue that is used to control postprandial glycemia levels in diabetic patients. The aim of this clinical trial was to compare the pharmacokinetics and pharmacodynamics of GP40071 (GP‐Asp) and… read more here.
Keywords: clinical pharmacology; pharmacology; insulin aspart; hyperinsulinemic euglycemic ... See more keywords
Barriers and Opportunities for Use of Patient Registries in Medicines Regulation
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DOI: 10.1002/cpt.1414
Abstract: © 2019 European Medicines Agency. Clinical Pharmacology & Therapeutics published by Wiley Periodicals, Inc. on behalf of American Society for Clinical Pharmacology and Therapeutics. This is an open access article under the terms of the… read more here.
Keywords: opportunities use; pharmacology therapeutics; use patient; pharmacology ... See more keywords
Clinical Pharmacology Perspectives on the Antiviral Activity of Azithromycin and Use in COVID‐19
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DOI: 10.1002/cpt.1857
Abstract: Azithromycin (AZ) is a broad‐spectrum macrolide antibiotic with a long half‐life and a large volume of distribution. It is primarily used for the treatment of respiratory, enteric, and genitourinary bacterial infections. AZ is not approved… read more here.
Keywords: use; covid clinical; treatment; azithromycin ... See more keywords
Asia‐Inclusive Clinical Research and Development Enabled by Translational Science and Quantitative Clinical Pharmacology: Toward a Culture That Challenges the Status Quo
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DOI: 10.1002/cpt.2591
Abstract: Access lag to innovative therapies in Asian populations continues to present a challenge to global health. Recent progressive changes in the global regulatory landscape, including newer guidelines, are enabling simultaneous global drug development and near‐simultaneous… read more here.
Keywords: clinical pharmacology; pharmacology; development; asia inclusive ... See more keywords
Clinical pharmacology of radiotheranostics in oncology.
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DOI: 10.1002/cpt.2598
Abstract: The combined use of diagnostic and therapeutic radioligands with the same molecular target, also known as theranostics, enables accurate patient selection, targeted therapy and prediction of treatment response. Radioiodine, bone-seeking radioligands and norepinephrine analogues have… read more here.
Keywords: pharmacology radiotheranostics; therapy; oncology; radiotheranostics oncology ... See more keywords
ECG Evaluation as Part of the Clinical Pharmacology Strategy in the Development of New Drugs: A Review of Current Practices and Opportunities Based on Five Case Studies
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Pharmacology"
DOI: 10.1002/jcph.2095
Abstract: The International Conference on Harmonization (ICH) E14 document was revised in 2015 to allow concentration–corrected QT interval (C–QTc) analysis to be applied to data from early clinical pharmacology studies to exclude a small drug‐induced effect… read more here.
Keywords: pharmacology; clinical pharmacology; qtc analysis; case ... See more keywords
Experimental and Clinical Pharmacology of Ziziphus jujuba Mills.
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DOI: 10.1002/ptr.5759
Abstract: Ziziphus jujuba Mills, ‘annab’ in Iran, ‘ber’ in India or ‘pomme sourette’ in France, is a species whose fruit (known warmly as ‘the fruits of life’ in China) has been consumed for centuries for its… read more here.
Keywords: experimental clinical; pharmacology; clinical pharmacology; ziziphus jujuba ... See more keywords
Developing confidence in basic prescribing skills during medical school: a longitudinal questionnaire study investigating the effects of a modified clinical pharmacology course
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Clinical Pharmacology"
DOI: 10.1007/s00228-018-2508-3
Abstract: PurposeTo investigate if increased focus on pharmacotherapy during medical school can increase students’ confidence in basic prescribing skills, that is, performing medication reviews and writing medication discharge summaries.MethodsIn 2016, the clinical pharmacology course in medical… read more here.
Keywords: medical school; confidence; course; pharmacology ... See more keywords
The Clinical Pharmacology of Elotuzumab
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DOI: 10.1007/s40262-017-0585-6
Abstract: Novel treatment options are needed to improve long-term outcomes for patients with multiple myeloma (MM). In this article, we comprehensively review the clinical pharmacology of elotuzumab, a first-in-class monoclonal anti-SLAMF7 antibody approved in combination with… read more here.
Keywords: exposure; pharmacology; clinical pharmacology; elotuzumab ... See more keywords
Clinical Pharmacology Considerations for Development of β Lactamase Inhibitor Combination with Antibiotics.
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DOI: 10.1055/a-0590-3791
Abstract: The shrinking drug pipeline for antibacterial drugs has made it very precious to discover and develop novel drugs in this space. In this context, the recent approvals of β lactamase inhibitors with either cephalosporin or… read more here.
Keywords: combination; pharmacology; clinical pharmacology; lactamase ... See more keywords
The clinical pharmacology of the medical treatment for overactive bladder in adults
Sign Up to like & getrecommendations! Published in 2020 at "Expert Review of Clinical Pharmacology"
DOI: 10.1080/17512433.2020.1779056
Abstract: ABSTRACT Introduction Overactive bladder is a prevalent symptom complex that affects the patient’s quality of life. Any disruption between the neuronal micturition pathway can lead to bladder overactivity. Neurogenic causes, myogenic causes, aging, bladder outlet… read more here.
Keywords: overactive bladder; treatment; bladder; pharmacology ... See more keywords