Measurement of Dimensions of Self-awareness of Memory Function and Their Association With Clinical Progression in Cognitively Normal Older Adults
Sign Up to like & getrecommendations! Published in 2023 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2023.9964
Abstract: Key Points Question Are separate, item-based measures of unawareness or heightened awareness of memory function associated with future progression from preclinical to symptomatic Alzheimer disease? Findings In this cohort study of 436 older adults, worse… read more here.
Keywords: older adults; awareness memory; progression; memory function ... See more keywords
Link between cognitive polygenic risk scores and clinical progression after a first-psychotic episode.
Sign Up to like & getrecommendations! Published in 2022 at "Psychological medicine"
DOI: 10.1017/s0033291722001544
Abstract: BACKGROUND Clinical intervention in early stages of psychotic disorders is crucial for the prevention of severe symptomatology trajectories and poor outcomes. Genetic variability is studied as a promising modulator of prognosis, thus novel approaches considering… read more here.
Keywords: risk scores; progression; polygenic risk; risk ... See more keywords
Hyperconnectivity Associated with Anosognosia Accelerating Clinical Progression in Amnestic Mild Cognitive Impairment.
Sign Up to like & getrecommendations! Published in 2021 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.1c00595
Abstract: The incidence and prevalence of anosognosia are highly variable in amnestic mild cognitive impairment (aMCI) patients. The study aims to explore the neuropathological mechanism of anosognosia in aMCI patients using two different but complementary technologies,… read more here.
Keywords: amci patients; mild cognitive; amnestic mild; amci ... See more keywords
Plasma Aβ42/Aβ40 and p-tau 181 Predict Long-Term Clinical Progression in a Cohort with Amnestic Mild Cognitive Impairment.
Sign Up to like & getrecommendations! Published in 2022 at "Clinical chemistry"
DOI: 10.1093/clinchem/hvac149
Abstract: BACKGROUND Previous studies reported the value of blood-based biomarkers in predicting Alzheimer disease (AD) progression among individuals with different disease stages. However, evidence regarding the value of these markers in those with amnestic mild cognitive… read more here.
Keywords: mild cognitive; progression; amnestic mild; cognitive impairment ... See more keywords
Clinical and Radiological Follow-up of Intraneural Perineuriomas.
Sign Up to like & getrecommendations! Published in 2018 at "Neurosurgery"
DOI: 10.1093/neuros/nyy476
Abstract: BACKGROUND Management of intraneural perineuriomas remains controversial, largely due to the lack of knowledge regarding the natural history of these lesions. OBJECTIVE To describe the typical radiological growth pattern of intraneural perineuriomas and to determine… read more here.
Keywords: length; intraneural perineuriomas; clinical progression; perineuriomas ... See more keywords
Sex differences in pain-related behaviors and clinical progression of disease in mouse models of colonic pain
Sign Up to like & getrecommendations! Published in 2022 at "Pain"
DOI: 10.1097/j.pain.0000000000002683
Abstract: Supplemental Digital Content is Available in the Text. Preclinical experiments in mouse models of visceral pain show marked sex differences in hypersensitivity, behavioral manifestation of pain-related responses, and clinical progression of disease. read more here.
Keywords: clinical progression; pain related; progression disease; mouse models ... See more keywords
Preventing clinical progression and need for treatment in patients on active surveillance for prostate cancer
Sign Up to like & getrecommendations! Published in 2018 at "Current Opinion in Urology"
DOI: 10.1097/mou.0000000000000455
Abstract: Purpose of review Active surveillance is an established treatment option for men with localized, low-risk prostate cancer (CaP). It entails the postponement of immediate therapy with the option of delayed intervention upon disease progression. The… read more here.
Keywords: clinical progression; active surveillance; surveillance; patients active ... See more keywords
Cerebrospinal fluid α-synuclein predicts neurodegeneration and clinical progression in non-demented elders
Sign Up to like & getrecommendations! Published in 2020 at "Translational Neurodegeneration"
DOI: 10.1186/s40035-020-00222-1
Abstract: Background Accumulating reports have suggested that α-synuclein is involved in the pathogenesis of Alzheimer’s disease (AD). As the cerebrospinal fluid (CSF) α-synuclein has been suggested as a potential biomarker of AD, this study was set… read more here.
Keywords: clinical progression; demented elders; neurodegeneration clinical; csf synuclein ... See more keywords
Early clinical progression in patients with gynecologic malignancies receiving immunomodulatory antibody therapy.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2017.35.15_suppl.e17087
Abstract: e17087Background: The success of immunomodulatory antibodies have led to their increasing investigation in GYN cancers. Many of these patients, however, discontinue the drugs early in treatment due... read more here.
Keywords: clinical progression; early clinical; progression patients; patients gynecologic ... See more keywords
Trinucleotide repeat expansion length as a predictor of the clinical progression of Fuchs’ Endothelial Corneal Dystrophy
Sign Up to like & getrecommendations! Published in 2019 at "PLoS ONE"
DOI: 10.1371/journal.pone.0210996
Abstract: Purpose To determine if CTG18.1 TNR expansion length prognosticates the clinical progression of Fuchs’ Endothelial Corneal Dystrophy (FECD). Methods This was a prospective cohort study. A total of 51 patients with newly diagnosed FECD were… read more here.
Keywords: length; clinical progression; corneal; expansion length ... See more keywords
Plasma Markers of Inflammation Linked to Clinical Progression and Decline During Preclinical AD
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2019.00229
Abstract: Objective To examine the prospective association between blood biomarkers of immune functioning (i.e., innate immune activation, adaptive immunity, and inflammation) and subsequent cognitive decline and clinical progression to mild cognitive impairment (MCI) in cognitively normal… read more here.
Keywords: clinical progression; immune activation; plasma; inflammation ... See more keywords