Preclinical and Clinical Proof of Concept for Metabolic Intervention in Diabetic Cardiomyopathy
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cardiac Failure"
DOI: 10.1016/j.cardfail.2019.07.218
Abstract: Introduction Hyperactivation of the polyol pathway (PP) contributes to development of diabetic complications such as diabetic cardiomyopathy (DbCM). Aldose reductase (AR), the rate-controlling enzyme in the PP, catalyzes NADPH-dependent reduction of glucose to sorbitol. Under… read more here.
Keywords: mice; concept metabolic; diabetic cardiomyopathy; proof concept ... See more keywords
From decoding the perception of tightness to a clinical proof of soothing effects derived from natural ingredients in a moisturizer
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Cosmetic Science"
DOI: 10.1111/ics.12797
Abstract: To decode the feeling of skin tightness after application of a cosmetic product and how to soothe this discomfort. To pursue this aim, we considered the ingredient's effect on stratum corneum (SC) biomechanics to differentiate… read more here.
Keywords: perception tightness; tightness clinical; decoding perception; proof soothing ... See more keywords
Pre-Clinical Proof of Concept: Intra-Carotid Injection of Autologous CD34-Positive Cells for Chronic Ischemic Stroke
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Medicine"
DOI: 10.3389/fmed.2022.681316
Abstract: This study was conducted to evaluate the safety and efficacy of human peripheral blood CD34 positive (CD34+) cells transplanted into a murine chronic stroke model to obtain pre-clinical proof of concept, prior to clinical testing.… read more here.
Keywords: pre clinical; clinical proof; cd34; cd34 cells ... See more keywords