Clinical Proteomics for the Analysis of Circulating Extracellular Vesicles.
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DOI: 10.1007/978-1-0716-1178-4_2
Abstract: In recent years, technical improvements in proteomics have allowed its rapid application for biomarker discovery, new drug target identification, and the study of disease progression and drug resistance. The clinical potential of circulating extracellular vesicles… read more here.
Keywords: extracellular vesicles; clinical proteomics; circulating extracellular; study ... See more keywords
Feature selection in clinical proteomics: with great power comes great reproducibility.
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DOI: 10.1016/j.drudis.2016.12.006
Abstract: In clinical proteomics, reproducible feature selection is unattainable given the standard statistical hypothesis-testing framework. This leads to irreproducible signatures with no diagnostic power. Instability stems from high P-value variability (p_var), which is inevitable and insolvable.… read more here.
Keywords: clinical proteomics; selection clinical; feature selection; power ... See more keywords
A Roadmap to Successful Clinical Proteomics.
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DOI: 10.1373/clinchem.2016.254664
Abstract: Clinical proteomics has come a long way and is at a point where the expertise, technology, assays, and knowledge have matured sufficiently to begin enabling personalized and precision medicine. Although traditional laboratory medicine seems to… read more here.
Keywords: medicine; roadmap successful; clinical proteomics; chemistry ... See more keywords
Clinical Proteomics of Biofluids in Haematological Malignancies
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DOI: 10.3390/ijms22158021
Abstract: Since the emergence of high-throughput proteomic techniques and advances in clinical technologies, there has been a steady rise in the number of cancer-associated diagnostic, prognostic, and predictive biomarkers being identified and translated into clinical use.… read more here.
Keywords: clinical proteomics; proteomics biofluids; disease; haematological malignancies ... See more keywords