Clinical sequencing identifies potential actionable alterations in a high rate of urachal and primary bladder adenocarcinomas
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DOI: 10.1002/cam4.5639
Abstract: Administration of targeted therapies provides a promising treatment strategy for urachal adenocarcinoma (UrC) or primary bladder adenocarcinoma (PBAC); however, the selection of appropriate drugs remains difficult. Here, we aimed to establish a routine compatible methodological… read more here.
Keywords: clinical sequencing; bladder; identifies potential; potential actionable ... See more keywords
Mutational Landscape of Metastatic Cancer Revealed from Prospective Clinical Sequencing of 10,000 Patients
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DOI: 10.1038/nm.4333
Abstract: Tumor molecular profiling is a fundamental component of precision oncology, enabling the identification of genomic alterations in genes and pathways that can be targeted therapeutically. The existence of recurrent targetable alterations across distinct histologically defined… read more here.
Keywords: tumor types; clinical sequencing; 000 patients; cancer ... See more keywords
Characterization of the genomic landscape and actionable mutations in Chinese breast cancers by clinical sequencing
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DOI: 10.1038/s41467-020-19342-3
Abstract: The remarkable advances in next-generation sequencing technology have enabled the wide usage of sequencing as a clinical tool. To promote the advance of precision oncology for breast cancer in China, here we report a large-scale… read more here.
Keywords: clinical sequencing; breast; chinese breast; breast cancer ... See more keywords
Clinical utility of comprehensive genomic profiling in Japan: Result of PROFILE-F study
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DOI: 10.1371/journal.pone.0266112
Abstract: Introduction Clinical sequencing has provided molecular and therapeutic insights into the field of clinical oncology. However, despite its significance, its clinical utility in Japanese patients remains unknown. Here, we examined the clinical utility of tissue-based… read more here.
Keywords: clinical sequencing; foundationone; clinical utility; utility comprehensive ... See more keywords