Clinical significance of FAT1 gene mutation and mRNA expression in patients with head and neck squamous cell carcinoma
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13171
Abstract: The FAT1 gene functions as a tumor suppressor or promoter and remains incompletely understood. We examined the clinical significance of FAT1 in head and neck squamous cell carcinoma (HNSCC) using four publicly available HNSCC cohorts… read more here.
Keywords: fat1 gene; hnscc; significance fat1; clinical significance ... See more keywords
Clinical significance of IgE in a large cohort of patients with moderate or severe chronic graft‐versus‐host disease
Sign Up to like & getrecommendations! Published in 2017 at "American Journal of Hematology"
DOI: 10.1002/ajh.24768
Abstract: in arterial and venous thromboelastography parameters: potential roles of shear stress and oxygen content. J Cardiothorac Vasc Anesth. 2002;16(5):551–554. [5] White H, Zollinger C, Jones M, Bird R. Can thromboelastography performed on kaolin-activated citrated samples… read more here.
Keywords: significance ige; large cohort; cohort patients; patients moderate ... See more keywords
Clinical significance of prothrombin G20210A mutation in homozygous patients
Sign Up to like & getrecommendations! Published in 2017 at "American Journal of Hematology"
DOI: 10.1002/ajh.24859
Abstract: (P< .0001), low hemoglobin (P5 .0009), high absolute lymphocyte count (P5 .02), higher serum lactate dehydrogenase levels (P5 .023), PB blast % (P< .0001), BM blast % (P< .0001), 2016WHO morphological subtype CMML-2 (P< .0001),… read more here.
Keywords: g20210a mutation; significance prothrombin; prothrombin g20210a; mutation homozygous ... See more keywords
Functions and clinical significance of mechanical tumor microenvironment: cancer cell sensing, mechanobiology and metastasis.
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DOI: 10.1002/cac2.12294
Abstract: Dynamic and heterogeneous interaction between tumor cells and the surrounding microenvironment fuels the occurrence, progression, invasion, and metastasis of solid tumors. In this process, the tumor microenvironment (TME) fractures cellular and matrix architecture normality through… read more here.
Keywords: metastasis; microenvironment; tumor microenvironment; cell sensing ... See more keywords
The clinical significance of interleukin‐6 in heart failure: results from the BIOSTAT‐CHF study
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Heart Failure"
DOI: 10.1002/ejhf.1482
Abstract: Inflammation is a central process in the pathophysiology of heart failure (HF), but trials targeting tumour necrosis factor (TNF)‐α were largely unsuccessful. Interleukin (IL)‐6 is an important inflammatory mediator and might constitute a potential pharmacologic… read more here.
Keywords: significance interleukin; interleukin heart; heart; heart failure ... See more keywords
Predicting pathogenicity of missense variants with weakly supervised regression
Sign Up to like & getrecommendations! Published in 2019 at "Human Mutation"
DOI: 10.1002/humu.23826
Abstract: Quickly growing genetic variation data of unknown clinical significance demand computational methods that can reliably predict clinical phenotypes and deeply unravel molecular mechanisms. On the platform enabled by the Critical Assessment of Genome Interpretation (CAGI),… read more here.
Keywords: supervised regression; regression; weakly supervised; pathogenicity ... See more keywords
The clinical significance of DJ‐1 and HE4 in patients with endometrial cancer
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DOI: 10.1002/jcla.22223
Abstract: The non‐invasive diagnostic approach for early detection of endometrial cancer (EC) remains limited. To date, human epididymis protein 4 (HE4) has been intensively studied but its diagnostic is controversial in EC. DJ‐1 is an oncoprotein… read more here.
Keywords: he4 patients; patients endometrial; endometrial cancer; cancer ... See more keywords
Clinical significance of serum bilirubin in primary Sjögren syndrome patients
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DOI: 10.1002/jcla.23090
Abstract: The purpose of our research was to demonstrate the clinical significance of serum bilirubin in primary Sjögren syndrome patients (pSS). read more here.
Keywords: gren syndrome; bilirubin primary; significance serum; primary gren ... See more keywords
Clinical significance of kallikrein 5 as a novel prognostic biomarker in gastric adenocarcinoma
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DOI: 10.1002/jcla.23958
Abstract: Gastric cancer is one of the most common cancers with unsatisfied prognosis. It is challenging to predict gastric cancer prognosis due to its highly heterogeneous nature. Kallikrein 5 (KLK5) belongs to the family of kallikreins,… read more here.
Keywords: gastric adenocarcinoma; kallikrein; clinical significance; novel prognostic ... See more keywords
Clinical significance of serum ferritin in patients with systemic sclerosis
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DOI: 10.1002/jcla.24597
Abstract: The purpose of this study was to explore the clinical significance of serum ferritin (SF) in patients with systemic sclerosis (SSc). read more here.
Keywords: systemic sclerosis; clinical significance; significance serum; ferritin patients ... See more keywords
Functional characterization and clinical significance of super‐enhancers in lung adenocarcinoma
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DOI: 10.1002/mc.23419
Abstract: Super‐enhancers (SEs) are important transcriptional regulators in tumorigenesis; however, the functional characterization and clinical significance of SEs in lung adenocarcinoma (LUAD) remain unclear. By using H3K27ac ChIP‐seq data of two LUAD cell lines and eight… read more here.
Keywords: functional characterization; clinical significance; characterization clinical; super enhancers ... See more keywords