Experimental and Clinical Strategies for Treating Spinocerebellar Ataxia Type 3
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DOI: 10.1016/j.neuroscience.2017.11.051
Abstract: Spinocerebellar ataxia type 3 (SCA3), or Machado-Joseph disease (MJD), is an autosomal dominant neurodegenerative disorder caused by the expansion of a polyglutamine (polyQ) tract in the ataxin-3 protein. To date, there is no effective therapy… read more here.
Keywords: ataxia type; spinocerebellar ataxia; strategies treating; clinical strategies ... See more keywords
Current Clinical Strategies of Pancreatic Cancer Treatment and Open Molecular Questions
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DOI: 10.3390/ijms20184543
Abstract: Pancreatic cancer is one of the most lethal malignancies and is associated with a poor prognosis. Surgery is considered the only potential curative treatment for pancreatic cancer, followed by adjuvant chemotherapy, but surgery is reserved… read more here.
Keywords: surgery; current clinical; treatment; pancreatic cancer ... See more keywords
Clinical strategies to manage adult glioblastoma patients without MGMT hypermethylation
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DOI: 10.7150/jca.63595
Abstract: Glioblastoma (GBM) is a highly malignant brain tumor with a dismal prognosis. Standard therapy for GBM comprises surgical resection, followed by radiotherapy plus concomitant and adjuvant temozolomide (TMZ) therapy. The methylation status of the O6-methylguanine… read more here.
Keywords: glioblastoma; strategies manage; manage adult; therapy ... See more keywords