Assessment of Concordance and Discordance Among Clinical Studies Posted as Preprints and Subsequently Published in High-Impact Journals
Sign Up to like & getrecommendations! Published in 2021 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2021.2110
Abstract: This cross-sectional study examines the concordance between clinical studies posted as preprints and subsequently published in high-impact journals, including key study characteristics, reported results, and study interpretations. read more here.
Keywords: clinical studies; subsequently published; studies posted; posted preprints ... See more keywords
Comparison of Clinical Study Results Reported in medRxiv Preprints vs Peer-reviewed Journal Articles
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2022.45847
Abstract: Key Points Question What is the concordance among sample size, primary end points, results for primary end points, and interpretations described in preprints of clinical studies posted on medRxiv that are subsequently published in peer-reviewed… read more here.
Keywords: published peer; clinical studies; primary end; peer reviewed ... See more keywords
Parameters from site classification to harmonize MRI clinical studies: Application to a multi‐site Parkinson's disease dataset
Sign Up to like & getrecommendations! Published in 2022 at "Human Brain Mapping"
DOI: 10.1002/hbm.25838
Abstract: Multi‐site MRI datasets are crucial for big data research. However, neuroimaging studies must face the batch effect. Here, we propose an approach that uses the predictive probabilities provided by Gaussian processes (GPs) to harmonize clinical‐based… read more here.
Keywords: clinical studies; classification; parkinson disease; site classification ... See more keywords
Cancer cachexia and skeletal muscle atrophy in clinical studies: what do we really know?
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cachexia, Sarcopenia and Muscle"
DOI: 10.1002/jcsm.12633
Abstract: Research investigators have shown a growing interest in investigating alterations underlying skeletal muscle wasting in patients with cancer. However, skeletal muscle dysfunctions associated with cancer cachexia have mainly been studied in preclinical models. In the… read more here.
Keywords: skeletal muscle; clinical studies; muscle; cancer cachexia ... See more keywords
Characteristics, level of evidence, and impact of clinical studies on peri-implantitis: 2017-2021.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of periodontology"
DOI: 10.1002/jper.23-0093
Abstract: BACKGROUND The level of evidence (LOE) is an important tool in current evidence-based practice and clinical research. However, in clinical studies on peri-implantitis, the present status of LOE and its association with research impact remains… read more here.
Keywords: clinical studies; 2017 2021; studies peri; evidence ... See more keywords
Response-adaptive treatment allocation for clinical studies with recurrent event and terminal event data.
Sign Up to like & getrecommendations! Published in 2021 at "Statistics in medicine"
DOI: 10.1002/sim.9235
Abstract: In long-term clinical studies, recurrent event data are frequently collected to contrast the efficacy of two different treatments. However, the recurrent event process can be stopped by a terminal event, such as death. For analyzing… read more here.
Keywords: clinical studies; recurrent event; treatment; terminal event ... See more keywords
Clinical Studies of Methionine-Restricted Diets for Cancer Patients.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8796-2_9
Abstract: Methionine (MET) restriction (MR) has been shown to arrest cancer growth and sensitizes tumors to chemotherapy. MR total parenteral nutrition (MR TPN) with a chemotherapy-containing amino acid solution ("AO-90") (lacking both MET and L-cysteine[CYS]) showed… read more here.
Keywords: clinical trial; studies methionine; clinical studies; cancer ... See more keywords
Facilitating Clinical Studies in Rare Diseases.
Sign Up to like & getrecommendations! Published in 2017 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-319-67144-4_6
Abstract: In recent years, there have been many scientific advances and new collaborations for rare diseases research and, ultimately, the health of patients living with rare diseases. However, for too many rare diseases, there still is… read more here.
Keywords: clinical studies; studies rare; etiology; rare diseases ... See more keywords
[Telemedicine in chronic heart failure-From clinical studies to standard care].
Sign Up to like & getrecommendations! Published in 2022 at "Der Internist"
DOI: 10.1007/s00108-022-01268-1
Abstract: Telemedicine has the potential to solve many current and especially future challenges in medical care. Using the example of heart failure (HF), the transition of telemedicine from clinical studies to standard care is presented. In… read more here.
Keywords: telemedicine; clinical studies; studies standard; care ... See more keywords
Safety profile of COVID-19 drugs in a real clinical setting
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Clinical Pharmacology"
DOI: 10.1007/s00228-021-03270-2
Abstract: Purpose The coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus has affected millions all over the world and has been declared pandemic, as of 11 March 2020. In… read more here.
Keywords: safety; adverse events; covid drugs; covid ... See more keywords
Practical guidelines for rigor and reproducibility in preclinical and clinical studies on cardioprotection
Sign Up to like & getrecommendations! Published in 2018 at "Basic Research in Cardiology"
DOI: 10.1007/s00395-018-0696-8
Abstract: Hans Erik Bøtker1 · Derek Hausenloy2,3,4,5,6 · Ioanna Andreadou7 · Salvatore Antonucci8 · Kerstin Boengler9 · Sean M. Davidson2 · Soni Deshwal8 · Yvan Devaux10 · Fabio Di Lisa8 · Moises Di Sante8 · Panagiotis… read more here.
Keywords: clinical studies; guidelines rigor; practical guidelines; rigor reproducibility ... See more keywords