A Bionic‐Homodimerization Strategy for Optimizing Modulators of Protein–Protein Interactions: From Statistical Mechanics Theory to Potential Clinical Translation
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202105179
Abstract: Emerging protein–protein interaction (PPI) modulators have brought out exciting ability as therapeutics in human diseases, but its clinical translation has been greatly hampered by the limited affinity. Inspired by the homodimerize structure of antibody, the… read more here.
Keywords: protein protein; clinical translation; affinity; homodimerization ... See more keywords
Targeted Cancer Immunotherapy: Nanoformulation Engineering and Clinical Translation
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202204335
Abstract: With the rapid growth of advanced nanoengineering strategies, there are great implications for therapeutic immunostimulators formulated in nanomaterials to combat cancer. It is crucial to direct immunostimulators to the right tissue and specific immune cells… read more here.
Keywords: targeted cancer; clinical translation; immune cells; cancer ... See more keywords
Steps on the Path to Clinical Translation: A workshop by the British and Irish Chapter of the ISMRM.
Sign Up to like & getrecommendations! Published in 2023 at "Magnetic resonance in medicine"
DOI: 10.1002/mrm.29704
Abstract: The British and Irish Chapter of the International Society for Magnetic Resonance in Medicine (BIC-ISMRM) held a workshop entitled "Steps on the path to clinical translation" in Cardiff, UK, on 7th September 2022. The aim… read more here.
Keywords: irish chapter; british irish; clinical translation; medicine ... See more keywords
Nanoparticle Drug Delivery Can Reduce the Hepatotoxicity of Therapeutic Cargo.
Sign Up to like & getrecommendations! Published in 2020 at "Small"
DOI: 10.1002/smll.201906360
Abstract: Hepatotoxicity is a key concern in the clinical translation of nanotherapeutics because preclinical studies have consistently shown that nanotherapeutics accumulates extensively in the liver. However, clinical-stage nanotherapeutics have not shown increased hepatotoxicity. Factors that can… read more here.
Keywords: drug delivery; reduce hepatotoxicity; hepatotoxicity; clinical translation ... See more keywords
The role of small extracellular vesicles in cerebral and myocardial ischemia—Molecular signals, treatment targets, and future clinical translation
Sign Up to like & getrecommendations! Published in 2021 at "STEM CELLS"
DOI: 10.1002/stem.3329
Abstract: The heart and the brain mutually interact with each other, forming a functional axis that is disturbed under conditions of ischemia. Stem cell‐derived extracellular vesicles (EVs) show great potential for the treatment of ischemic stroke… read more here.
Keywords: extracellular vesicles; heart; treatment; clinical translation ... See more keywords
Successful development and clinical translation of a novel anterior lamellar artificial cornea
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Tissue Engineering and Regenerative Medicine"
DOI: 10.1002/term.2951
Abstract: Blindness due to corneal diseases is a common pathology affecting up to 23 million individuals worldwide. The tissue‐engineered anterior human cornea, which is currently being tested in a Phase I/II clinical trial to treat severe… read more here.
Keywords: development clinical; cornea; successful development; translation ... See more keywords
Red blood cells membrane-derived nanoparticles: Applications and key challenges in their clinical translation.
Sign Up to like & getrecommendations! Published in 2022 at "Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology"
DOI: 10.1002/wnan.1776
Abstract: Cellular membrane-derived nanoparticles, particularly of red blood cells (RBCs), represent an emerging class of drug delivery systems. The lack of nucleus and organelles in these cells makes them easy to process and empty out intracellular… read more here.
Keywords: derived nanoparticles; clinical translation; red blood; blood cells ... See more keywords
Organoids technology for advancing the clinical translation of cancer nanomedicine.
Sign Up to like & getrecommendations! Published in 2023 at "Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology"
DOI: 10.1002/wnan.1892
Abstract: The past decades have witnessed the rapid development and widespread application of nanomedicines in cancer treatment; however, the clinical translation of experimental findings has been low, as evidenced by the low percentage of commercialized nanomedicines.… read more here.
Keywords: nanotechnology; clinical translation; biology; tumor ... See more keywords
Challenges in nanomedicine clinical translation
Sign Up to like & getrecommendations! Published in 2020 at "Drug Delivery and Translational Research"
DOI: 10.1007/s13346-020-00740-5
Abstract: New nanomedicine formulations and novel applications of nanomedicinal drugs are reported on an almost daily basis. While academic progress and societal promise continue to shoot for the stars, industrial acceptance and clinical translation are being… read more here.
Keywords: nanomedicine clinical; challenges nanomedicine; translation; clinical translation ... See more keywords
Perspectives on the New ISSCR Guidelines for Stem Cell Research and Clinical Translation
Sign Up to like & getrecommendations! Published in 2018 at "Current Stem Cell Reports"
DOI: 10.1007/s40778-018-0138-4
Abstract: Purpose of ReviewThis review seeks to highlight key elements of the ISSCR 2016 Guidelines for Stem Cell Research and Clinical Translation, describe apparent influences on the Guidelines, provide an analysis of the utility and the potential… read more here.
Keywords: stem cell; research; clinical translation; cell research ... See more keywords
Critical review of nucleic acid nanotechnology to identify gaps and inform a strategy for accelerated clinical translation.
Sign Up to like & getrecommendations! Published in 2021 at "Advanced drug delivery reviews"
DOI: 10.1016/j.addr.2021.114081
Abstract: With numerous recent advances, the field of therapeutic nucleic acid nanotechnology is now poised for clinical translation supported by several examples of FDA-approved nucleic acid nanoformulations including two recent mRNA-based COVID-19 vaccines. Within this rapidly… read more here.
Keywords: clinical translation; acid nanotechnology; nanotechnology; nucleic acid ... See more keywords