How Should Representation of Subjects With LEP Become More Equitable in Clinical Trials?
Sign Up to like & getrecommendations! Published in 2022 at "AMA journal of ethics"
DOI: 10.1001/amajethics.2022.319
Abstract: Underrepresentation of individuals with limited English proficiency (LEP) who speak Spanish is ongoing in phase 3 biomedical clinical trials and exacerbates health inequity. This article suggests strategies for increasing representation of Spanish speakers in clinical… read more here.
Keywords: clinical trials; representation subjects; subjects lep; become equitable ... See more keywords
Vitamin D Supplementation and Cardiovascular Disease Risks in More Than 83 000 Individuals in 21 Randomized Clinical Trials: A Meta-analysis.
Sign Up to like & getrecommendations! Published in 2019 at "JAMA cardiology"
DOI: 10.1001/jamacardio.2019.1870
Abstract: Importance Observational studies have reported an association between low serum vitamin D levels and elevated risk of cardiovascular disease (CVD) events, but such studies cannot prove causation because of possible unmeasured confounding. Objective We conducted… read more here.
Keywords: randomized clinical; mortality; clinical trials; vitamin supplementation ... See more keywords
Characteristics of Clinical Trial Sites for Novel Transcatheter Mitral and Tricuspid Valvular Therapies.
Sign Up to like & getrecommendations! Published in 2022 at "JAMA cardiology"
DOI: 10.1001/jamacardio.2022.4457
Abstract: Importance Racial and ethnic minority and socioeconomically disadvantaged patients have been underrepresented in randomized clinical trials. Efforts have focused on enhancing inclusion of minority groups at sites participating at clinical trials; however, there may be… read more here.
Keywords: mitral tricuspid; clinical trials; novel transcatheter; trial ... See more keywords
Diagnosis uPGrade-Advances in Pyoderma Gangrenosum.
Sign Up to like & getrecommendations! Published in 2018 at "JAMA dermatology"
DOI: 10.1001/jamadermatol.2017.5979
Abstract: In this issue of JAMA Dermatology, 2 large, well-constructed studies remind dermatologists that even though pyoderma gangrenosum (PG) is a quintessential disease in medical dermatology, we still need data to better define the disease and… read more here.
Keywords: validation; dermatology; diagnosis; disease ... See more keywords
Assessment of Changes in Diversity in Dermatology Clinical Trials Between 2010-2015 and 2015-2020: A Systematic Review.
Sign Up to like & getrecommendations! Published in 2022 at "JAMA dermatology"
DOI: 10.1001/jamadermatol.2021.5596
Abstract: Importance Although there have been increased efforts in dermatologic research to improve representation of patient sex, race, and ethnicity, there are limited data evaluating resulting changes. Objective To characterize the diversity of participants in dermatologic… read more here.
Keywords: 2010 2015; clinical trials; review; dermatology ... See more keywords
Strategies to Improve Adherence to Skin Self-examination and Other Self-management Practices in People at High Risk of Melanoma: A Scoping Review of Randomized Clinical Trials.
Sign Up to like & getrecommendations! Published in 2023 at "JAMA dermatology"
DOI: 10.1001/jamadermatol.2022.6478
Abstract: Importance Adherence, both in research trials and in clinical practice, is crucial to the success of interventions. There is limited guidance on strategies to increase adherence and the measurement and reporting of adherence in trials… read more here.
Keywords: adherence; management practices; clinical trials; self management ... See more keywords
Biosimilars for the Treatment of Psoriasis: A Systematic Review of Clinical Trials and Observational Studies.
Sign Up to like & getrecommendations! Published in 2023 at "JAMA dermatology"
DOI: 10.1001/jamadermatol.2023.1338
Abstract: Importance Biosimilars have the potential to reduce costs for the management of moderate-to-severe psoriasis compared with originators. However, the extrapolation of evidence enables the approval of a biosimilar for use in indications held by the… read more here.
Keywords: safety; clinical trials; biosimilars treatment; evidence ... See more keywords
Evaluation of Journal Registration Policies and Prospective Registration of Randomized Clinical Trials of Nonregulated Health Care Interventions.
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DOI: 10.1001/jamainternmed.2018.8009
Abstract: Importance Many interventions that are important to the health care of patients are not subject to regulation by the US Food and Drug Administration (FDA) or comparable regulatory bodies in other nations. Objective To determine… read more here.
Keywords: registration policies; health care; prospective registration; clinical trials ... See more keywords
Assessment of Nonfatal Myocardial Infarction as a Surrogate for All-Cause and Cardiovascular Mortality in Treatment or Prevention of Coronary Artery Disease: A Meta-analysis of Randomized Clinical Trials.
Sign Up to like & getrecommendations! Published in 2021 at "JAMA internal medicine"
DOI: 10.1001/jamainternmed.2021.5726
Abstract: Importance Although nonfatal myocardial infarction (MI) is associated with an increased risk of mortality, evidence validating nonfatal MI as a surrogate end point for all-cause or cardiovascular (CV) mortality is lacking. Objective To examine whether… read more here.
Keywords: cause; cause mortality; randomized clinical; mortality ... See more keywords
Global Public Attitudes About Clinical Research and Patient Experiences With Clinical Trials
Sign Up to like & getrecommendations! Published in 2018 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2018.2969
Abstract: This survey study reviews the findings of the attitudes, perceptions, and experiences of clinical trials among clinical trial participants and nonparticipants in 68 countries. read more here.
Keywords: attitudes clinical; experiences clinical; clinical trials; global public ... See more keywords
Association of Concomitant Use of Cholinesterase Inhibitors or Memantine With Cognitive Decline in Alzheimer Clinical Trials
Sign Up to like & getrecommendations! Published in 2018 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2018.4080
Abstract: Key Points Question Are cholinesterase inhibitors or memantine associated with cognitive outcomes in clinical trials for Alzheimer disease? Findings In this meta-analysis, participants receiving cholinesterase inhibitors or memantine had 1.4 points per year difference on… read more here.
Keywords: use cholinesterase; clinical trials; inhibitors memantine; association concomitant ... See more keywords