Reporting on circulating tumor DNA monitoring in metastatic cancer—From clinical validity to clinical utility
Sign Up to like & getrecommendations! Published in 2022 at "Cancer"
DOI: 10.1002/cncr.34168
Abstract: This commentary attempts to discuss the required standardization of circulating tumor DNA (ctDNA) analyses and thereby improve the clinical validity of ctDNA monitoring in the metastatic setting of solid tumors. read more here.
Keywords: circulating tumor; monitoring metastatic; clinical validity; tumor dna ... See more keywords
Clinical validity of expanded carrier screening: Evaluating the gene‐disease relationship in more than 200 conditions
Sign Up to like & getrecommendations! Published in 2020 at "Human Mutation"
DOI: 10.1002/humu.24033
Abstract: Clinical guidelines consider expanded carrier screening (ECS) to be an acceptable method of carrier screening. However, broader guideline support and payer adoption require evidence for associations between the genes on ECS panels and the conditions… read more here.
Keywords: carrier screening; gene; gene disease; clinical validity ... See more keywords
Assessing the strength of evidence for genes implicated in fatty acid oxidation disorders using the ClinGen clinical validity framework.
Sign Up to like & getrecommendations! Published in 2019 at "Molecular genetics and metabolism"
DOI: 10.1016/j.ymgme.2019.07.008
Abstract: Newborn screening is an incredibly useful tool for the early identification of many metabolic disorders, including fatty acid oxidation (FAO) disorders. In many cases, molecular tests are necessary to reach a final diagnosis, highlighting the… read more here.
Keywords: fatty acid; evidence; clinical validity; acid oxidation ... See more keywords
The clinical validity of miR-126 as a prognostic marker in epithelial ovarian cancer
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DOI: 10.1097/md.0000000000033085
Abstract: Background: Ovarian cancer is the leading cause of gynecological cancer related death in females worldwide. Our previous study demonstrated that decreased expression of microRNA (miR-126) promoted ovarian cancer angiogenesis and invasion by targeting VEGF-A. This… read more here.
Keywords: cancer; ovarian cancer; clinical validity; validity mir ... See more keywords
Clinical Validity Assessment of Integrated Dose Range Checking Tool in a Tertiary Care Hospital Using an Electronic Health Information System
Sign Up to like & getrecommendations! Published in 2021 at "Hospital Pharmacy"
DOI: 10.1177/0018578719867663
Abstract: Background/purpose: The electronic clinical decision support system (CDSS) is mainly used to assist health care providers in their decision-making process. CDSS includes the dose range checking (DRC) tool. This study aims to evaluate the clinical… read more here.
Keywords: tool; clinical validity; drc alerts; health ... See more keywords
Meta-analysis of predictive models to assess the clinical validity and utility for patient-centered medical decision making: application to the CAncer of the Prostate Risk Assessment (CAPRA)
Sign Up to like & getrecommendations! Published in 2019 at "BMC Medical Informatics and Decision Making"
DOI: 10.1186/s12911-018-0727-2
Abstract: BackgroundThe Cancer of the Prostate Risk Assessment (CAPRA) score was designed and validated several times to predict the biochemical recurrence-free survival after a radical prostatectomy. Our objectives were, first, to study the clinical validity of… read more here.
Keywords: risk; patient centered; utility; capra score ... See more keywords
Clinical Validity of 16α-[18F]Fluoro-17β-Estradiol Positron Emission Tomography/Computed Tomography to Assess Estrogen Receptor Status in Newly Diagnosed Metastatic Breast Cancer
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.22.00400
Abstract: PURPOSE Determining the estrogen receptor (ER) status is essential in metastatic breast cancer (MBC) management. Whole-body ER imaging with 16α-[18F]fluoro-17β-estradiol positron emission tomography ([18F]FES-PET) is increasingly used for this purpose. To establish the clinical validity… read more here.
Keywords: metastasis; 18f fes; fes pet; status ... See more keywords
Clinical Validity, Understandability, and Actionability of Online Cardiovascular Disease Risk Calculators: Systematic Review
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DOI: 10.2196/jmir.8538
Abstract: Background Online health information is particularly important for cardiovascular disease (CVD) prevention, where lifestyle changes are recommended until risk becomes high enough to warrant pharmacological intervention. Online information is abundant, but the quality is often… read more here.
Keywords: risk; risk calculators; clinical validity; cvd ... See more keywords