Pre‐clinical in vitro infection models
Sign Up to like & getrecommendations! Published in 2017 at "Current Opinion in Pharmacology"
DOI: 10.1016/j.coph.2017.09.011
Abstract: HIGHLIGHTSIn vitro systems allow determination of dose and schedule for new drugs.Identifying this allows better patient outcomes and de‐risks drug development.The HFIM allows identification of dose and schedule for resistance suppression. &NA; Given the current… read more here.
Keywords: dose schedule; clinical vitro; pre clinical; vitro infection ... See more keywords
Clinical and in vitro evaluation of red blood cells collected and stored in a non‐DEHP plasticized bag system
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DOI: 10.1111/vox.13344
Abstract: Di‐ethyl‐hexyl‐phthalate (DEHP) is currently the main plasticizer used for whole blood collection systems. However, in Europe, after May 2025, DEHP may no longer be used above 0.1% (w/w) in medical devices. DEHP stabilizes red cell… read more here.
Keywords: collected stored; vitro evaluation; evaluation red; blood ... See more keywords
Pre-Clinical In-Vitro Studies on Parameters Governing Immune Complex Formation
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DOI: 10.3390/pharmaceutics14061254
Abstract: The success of biotherapeutics is often challenged by the undesirable events of immunogenicity in patients, characterized by the formation of anti-drug antibodies (ADA). Under specific conditions, the ADAs recognizing the biotherapeutic can trigger the formation… read more here.
Keywords: vitro studies; studies parameters; pre clinical; formation ... See more keywords