Effect of intravenous immunoglobulin (IVIg) on primate complement-dependent cytotoxicity of genetically engineered pig cells: relevance to clinical xenotransplantation
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DOI: 10.1038/s41598-020-68505-1
Abstract: Triple-knockout (TKO) pigs may be ideal sources of organs for clinical xenotransplantation because many humans have no preformed antibody to TKO pig cells. Intravenous immunoglobulin (IVIg) is widely used for severe infection or the treatment/prevention… read more here.
Keywords: pig; clinical xenotransplantation; pig cells; ivig ... See more keywords
Clinical xenotransplantation seems close: Ethical issues persist.
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DOI: 10.1111/aor.14255
Abstract: Scientific barriers that have prevented successful xenotransplantation are being breached, yet many ethical issues remain. Some are broad issues that accompany the adoption of novel and expensive technologies, and some are unique to xenotransplantation. Major… read more here.
Keywords: ethical issues; close ethical; seems close; xenotransplantation seems ... See more keywords
Why was PERV not transmitted during preclinical and clinical xenotransplantation trials and after inoculation of animals?
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DOI: 10.1186/s12977-018-0411-8
Abstract: Porcine endogenous retroviruses (PERVs) are present in the genome of all pigs, they infect certain human cells and therefore pose a special risk for xenotransplantation using pig cells, tissues and organs. Xenotransplantation is being developed… read more here.
Keywords: xenotransplantation trials; clinical xenotransplantation; transmitted preclinical; xenotransplantation ... See more keywords