Pharmacological evaluation of clinically relevant concentrations of (2R,6R)-hydroxynorketamine
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DOI: 10.1016/j.neuropharm.2019.04.019
Abstract: Ketamine is a rapid-onset antidepressant whose efficacy long outlasts its pharmacokinetics. Multiple studies suggest ketamine's antidepressant effects require increased α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR)-dependent currents, which have recently been exclusively attributed to its N-methyl-d-aspartate receptor-inactive metabolite… read more here.
Keywords: hnk concentrations; clinically antidepressant; ketamine; pharmacological evaluation ... See more keywords