Supramolecular Nanofibrils Formed by Coassembly of Clinically Approved Drugs for Tumor Photothermal Immunotherapy.
Sign Up to like & getrecommendations! Published in 2021 at "Advanced materials"
DOI: 10.1002/adma.202100595
Abstract: Pancreatic cancer, one of the most lethal malignancies, compromises the performance of traditional therapeutic regimens in the clinic because of stromal resistance to systemic drug delivery and poor prognosis caused by tumor metastasis. Therefore, a… read more here.
Keywords: photothermal immunotherapy; clinically approved; coassembly clinically; supramolecular nanofibrils ... See more keywords
Half-Sandwich Ruthenium Arene Complexes Bearing Clinically Approved Drugs as Ligands: The Importance of Metal-Drug Synergism in Metallodrug Design.
Sign Up to like & getrecommendations! Published in 2023 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.2c01027
Abstract: A novel strategy in metallodrug discovery today is incorporating clinically approved drugs into metal complexes as coordinating ligands. Using this strategy, various drugs have been repurposed to prepare organometallic complexes to overcome the resistance of… read more here.
Keywords: clinically approved; approved drugs; drug synergism; half sandwich ... See more keywords
The clinically approved antiviral drug sofosbuvir inhibits Zika virus replication
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep40920
Abstract: Zika virus (ZIKV) is a member of the Flaviviridae family, along with other agents of clinical significance such as dengue (DENV) and hepatitis C (HCV) viruses. Since ZIKV causes neurological disorders during fetal development and… read more here.
Keywords: sofosbuvir inhibits; sofosbuvir; drug; clinically approved ... See more keywords
Corrigendum: The clinically approved antiviral drug sofosbuvir inhibits Zika virus replication
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep46772
Abstract: Scientific Reports 7: Article number: 40920; published online 18 January 2017; updated on 24 April 2017 The Competing Financial Interests section in this Article is incorrect and should read: “Dr. Karin Bruning is a member… read more here.
Keywords: antiviral drug; sofosbuvir inhibits; clinically approved; drug sofosbuvir ... See more keywords
Prolonging neutrophil room temperature storage with clinically-approved solutions: Implications for granulocyte transfusion.
Sign Up to like & getrecommendations! Published in 2024 at "Journal of leukocyte biology"
DOI: 10.1093/jleuko/qiae258
Abstract: INTRODUCTION Granulocyte concentrates (GC) are leukocyte preparations enriched in neutrophils that can potentially save neutropenic patients from life-threatening, antimicrobial-resistant infections. The main challenge of GC transfusions is preserving the viability and antimicrobial activity of neutrophils… read more here.
Keywords: viability; room temperature; storage; clinically approved ... See more keywords
Selective delivery of clinically approved tubulin binding agents through covalent conjugation to an active targeting moiety.
Sign Up to like & getrecommendations! Published in 2022 at "Current medicinal chemistry"
DOI: 10.2174/0929867329666220401105929
Abstract: The efficacy and tolerability of tubulin binding agents are hampered by their low specificity for cancer cells, like most clinically used anticancer agents. To improve specificity, tubulin binding agents have been covalently conjugated to agents… read more here.
Keywords: clinically approved; delivery clinically; tubulin binding; selective delivery ... See more keywords
Potential applications of JAK inhibitors, clinically approved drugs against autoimmune diseases, in cancer therapy
Sign Up to like & getrecommendations! Published in 2024 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2023.1326281
Abstract: Disturbances in immunoregulation may lead to both cancer and autoimmune diseases. Many therapeutic drugs for autoimmune diseases also display anti-tumor efficacy. The Janus kinase/signal transducer and activator of transcription signaling pathways are involved in the… read more here.
Keywords: drugs autoimmune; cancer; janus kinase; clinically approved ... See more keywords
Silver Nanoparticle Conjugation-Enhanced Antibacterial Efficacy of Clinically Approved Drugs Cephradine and Vildagliptin
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DOI: 10.3390/antibiotics7040100
Abstract: This paper sets out to determine whether silver nanoparticles conjugation enhance the antibacterial efficacy of clinically approved drugs. Silver conjugated Cephradine and Vildagliptin were synthesized and thoroughly characterized by ultraviolet visible spectrophotometry (UV-vis), Fourier transform… read more here.
Keywords: cephradine vildagliptin; approved drugs; clinically approved; silver nanoparticle ... See more keywords
Target Antigen Attributes and Their Contributions to Clinically Approved Antibody-Drug Conjugates (ADCs) in Haematopoietic and Solid Cancers
Sign Up to like & getrecommendations! Published in 2023 at "Cancers"
DOI: 10.3390/cancers15061845
Abstract: Simple Summary Antibody-Drug Conjugates (ADCs) provide effective anti-cancer treatments. ADC development requires the identification of appropriate tumour-associated antigens that can be targeted by the ADC to effectively kill cancer cells while minimising damage to healthy… read more here.
Keywords: clinically approved; drug conjugates; conjugates adcs; target antigen ... See more keywords