Clinically Meaningful Magnetic Resonance Endpoints Sensitive to Preataxic Spinocerebellar Ataxia Types 1 and 3
Sign Up to like & getrecommendations! Published in 2022 at "Annals of Neurology"
DOI: 10.1002/ana.26573
Abstract: This study was undertaken to identify magnetic resonance (MR) metrics that are most sensitive to early changes in the brain in spinocerebellar ataxia type 1 (SCA1) and type 3 (SCA3) using an advanced multimodal MR… read more here.
Keywords: magnetic resonance; clinically meaningful; meaningful magnetic; spinocerebellar ataxia ... See more keywords
Clinically meaningful change for the chair stand test: monitoring mobility in integrated care for older people
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cachexia, Sarcopenia and Muscle"
DOI: 10.1002/jcsm.13042
Abstract: Clinically meaningful changes in the five‐repetition chair stand test are essential for monitoring mobility in integrated care for older people. Recommendations for the clinically meaningful change of the chair stand test are not well known.… read more here.
Keywords: mobility integrated; stand test; chair stand; monitoring mobility ... See more keywords
Prostate Cancer in Older Adults: Risk of Clinically Meaningful Disease, the Role of Screening and Special Considerations
Sign Up to like & getrecommendations! Published in 2021 at "Current Oncology Reports"
DOI: 10.1007/s11912-021-01118-7
Abstract: Prostate cancer is the second most common cancer in men in the USA and several studies suggest more aggressive disease in older patients. However, screening remains controversial, especially in the older patient population. Aggressive prostate… read more here.
Keywords: risk clinically; disease; prostate cancer; cancer ... See more keywords
Literature Review of Fatigue Scales and Association with Clinically Meaningful Improvements in Outcomes Among Patients With and Without Paroxysmal Nocturnal Hemoglobinuria
Sign Up to like & getrecommendations! Published in 2022 at "Advances in Therapy"
DOI: 10.1007/s12325-022-02111-7
Abstract: Paroxysmal nocturnal hemoglobinuria (PNH) is a rare blood disorder characterized by anemia and debilitating fatigue. Limited evidence characterizes the association between hemoglobin, an indicator of anemia and disease activity, and patient-reported fatigue scales. This review… read more here.
Keywords: patients without; meaningful improvements; clinically meaningful; among patients ... See more keywords
Assessment of Clinically Meaningful Improvements in Self-Reported Walking Ability in Participants with Multiple Sclerosis: Results from the Randomized, Double-Blind, Phase III ENHANCE Trial of Prolonged-Release Fampridine
Sign Up to like & getrecommendations! Published in 2018 at "CNS Drugs"
DOI: 10.1007/s40263-018-0586-5
Abstract: BackgroundWalking impairment is a hallmark of multiple sclerosis (MS). It affects > 90% of individuals over time, reducing independence and negatively impacting health-related quality of life, productivity, and daily activities. Walking impairment is consistently reported as one… read more here.
Keywords: improvement; multiple sclerosis; placebo; clinically meaningful ... See more keywords
Obstructive sleep apnea and the metabolic syndrome: The road to clinically-meaningful phenotyping, improved prognosis, and personalized treatment.
Sign Up to like & getrecommendations! Published in 2018 at "Sleep medicine reviews"
DOI: 10.1016/j.smrv.2018.08.009
Abstract: Obstructive sleep apnea (OSA) is an increasingly prevalent sleep disorder characterized by upper airway obstruction during sleep, resulting in breathing pauses, intermittent hypoxia, and fragmented sleep. In parallel, the constellation of adverse health outcomes associated… read more here.
Keywords: metabolic syndrome; obstructive sleep; clinically meaningful; sleep apnea ... See more keywords
Assessing Clinically Meaningful Hypercoagulability after COVID-19 Vaccination: A Longitudinal Study
Sign Up to like & getrecommendations! Published in 2022 at "Thrombosis and Haemostasis"
DOI: 10.1055/a-1788-5206
Abstract: A large number of daily requests to exclude possible prothrombotic risk factors for coronavirus disease 2019 (COVID-19) vaccines were received. Our aim was to longitudinally evaluate coagulation profiles in a series of healthy subjects who… read more here.
Keywords: hypercoagulability; meaningful hypercoagulability; covid vaccination; clinically meaningful ... See more keywords
Clinically meaningful changes in efficacy outcomes in chronic rhinosinusitis with nasal polyposis
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DOI: 10.1097/aci.0000000000000874
Abstract: Purpose of review Chronic rhinosinusitis with nasal polyps (CRSwNP) carries a high disease burden, and many studies have been done investigating the efficacy of various medical and surgical therapies. However, outcome metrics have varied across… read more here.
Keywords: outcome metrics; chronic rhinosinusitis; rhinosinusitis nasal; clinically meaningful ... See more keywords
Simulation-Based Mastery Learning for Thoracentesis Skills Improves Patient Outcomes: A Randomized Trial
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DOI: 10.1097/acm.0000000000001965
Abstract: Purpose Physicians-in-training often perform bedside thoracenteses in academic medical centers, and complications are more common among less experienced clinicians. Simulation-based mastery learning (SBML) is one potential solution to this problem. This study evaluated the effects… read more here.
Keywords: medicine; sbml trained; thoracentesis; clinically meaningful ... See more keywords
Fenfluramine HCl (Fintepla®) provides long‐term clinically meaningful reduction in seizure frequency: Analysis of an ongoing open‐label extension study
Sign Up to like & getrecommendations! Published in 2020 at "Epilepsia"
DOI: 10.1111/epi.16722
Abstract: Fenfluramine has been shown to provide clinically meaningful and statistically significant reductions in convulsive seizure frequency in children and adolescents (aged 2‐18 years) with Dravet syndrome in two randomized, placebo‐controlled clinical trials. The objective of… read more here.
Keywords: seizure frequency; clinically meaningful; label extension; open label ... See more keywords
Joint Coordinate System Using Functional Axes Achieves Clinically Meaningful Kinematics of the Tibiofemoral Joint as Compared to the International Society of Biomechanics (ISB) Recommendation.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of biomechanical engineering"
DOI: 10.1115/1.4056654
Abstract: Quantification of clinically meaningful tibiofemoral motions requires a joint coordinate system (JCS) with motions free from kinematic crosstalk errors. Objectives were to use a JCS with literature-backed functional axes (FUNC) and a JCS recommended by… read more here.
Keywords: kinematics; jcs; func jcs; joint ... See more keywords