The clinically relevant triple mutation in the mtND1 gene inactivates Escherichia coli complex I.
Sign Up to like & getrecommendations! Published in 2022 at "FEBS letters"
DOI: 10.1002/1873-3468.14325
Abstract: NADH:ubiquinone oxidoreductase (respiratory complex I) plays a major role in cellular energy metabolism. Complex I deficiencies are the most common cause of mitochondrial dysfunction. Patients suffering from a variety of neurodegenerative diseases carry numerous mutations… read more here.
Keywords: relevant triple; escherichia coli; triple mutation; mtnd1 ... See more keywords
Patient-Derived Prostate Cancer Explants: A Clinically Relevant Model to Assess siRNA-Based Nanomedicines.
Sign Up to like & getrecommendations! Published in 2020 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202001594
Abstract: Over the last thirty years, research in nanomedicine has widely been focused on applications in cancer therapeutics. However, despite the plethora of reported nanoscale drug delivery systems that can successfully eradicate solid tumor xenografts in… read more here.
Keywords: relevant model; prostate cancer; model; clinically relevant ... See more keywords
Performance characterization of a prototype dual-layer cone-beam computed tomography system.
Sign Up to like & getrecommendations! Published in 2021 at "Medical physics"
DOI: 10.1002/mp.15240
Abstract: PURPOSE Conventional cone-beam computed tomography CT (CBCT) provides limited discrimination between low-contrast tissues. Furthermore, it is limited to full-spectrum energy integration. A dual-energy CBCT system could be used to separate photon energy spectra with the… read more here.
Keywords: system; energy; dual layer; clinically relevant ... See more keywords
Clinically relevant discordances identified after tertiary reassessment of fetuses with isolated congenital diaphragmatic hernia
Sign Up to like & getrecommendations! Published in 2017 at "Prenatal Diagnosis"
DOI: 10.1002/pd.5060
Abstract: Fetoscopic endoluminal tracheal occlusion (FETO) may improve outcome of severe isolated congenital diaphragmatic hernia (iCDH). We aimed to identify any discrepancy between initial assessment at the referring hospital and the evaluation at the fetal surgery… read more here.
Keywords: congenital diaphragmatic; relevant discordances; diaphragmatic hernia; clinically relevant ... See more keywords
Risk of Clinically Relevant Pericardial Effusion After Pediatric Cardiac Surgery
Sign Up to like & getrecommendations! Published in 2018 at "Pediatric Cardiology"
DOI: 10.1007/s00246-018-2031-4
Abstract: Pericardial effusion (PE) after pediatric cardiac surgery is common. Because of the lack of a uniform classification of the presence and severity of PE, we evaluated PE altering clinical management: clinically relevant PE. Risk factors… read more here.
Keywords: surgery; risk; cardiac surgery; clinically relevant ... See more keywords
Early Fistulography Can Predict Whether Biochemical Leakage Develops to Clinically Relevant Postoperative Pancreatic Fistula
Sign Up to like & getrecommendations! Published in 2019 at "World Journal of Surgery"
DOI: 10.1007/s00268-019-05315-1
Abstract: Background As complete prevention of postoperative pancreatic fistula (POPF) after pancreatic surgery remains difficult, many risk factors for clinically relevant POPF (CR-POPF) have been reported. However, their clinical impact could be limited because all previous… read more here.
Keywords: popf; fistulography; pancreatic fistula; biochemical leakage ... See more keywords
Detection of relevant extracardiac findings on coronary computed tomography angiography vs. invasive coronary angiography
Sign Up to like & getrecommendations! Published in 2021 at "European Radiology"
DOI: 10.1007/s00330-021-07967-x
Abstract: To compare the detection of relevant extracardiac findings (ECFs) on coronary computed tomography angiography (CTA) and invasive coronary angiography (ICA) and evaluate the potential clinical benefit of their detection. This is the prespecified subanalysis of… read more here.
Keywords: detection; ecfs; angiography; ica ... See more keywords
Posterior Urethral Valves Outcomes Prediction (PUVOP): a machine learning tool to predict clinically relevant outcomes in boys with posterior urethral valves
Sign Up to like & getrecommendations! Published in 2021 at "Pediatric Nephrology"
DOI: 10.1007/s00467-021-05321-3
Abstract: Early kidney and anatomic features may be predictive of future progression and need for additional procedures in patients with posterior urethral valve (PUV). The objective of this study was to use machine learning (ML) to… read more here.
Keywords: index; relevant outcomes; clinically relevant; posterior urethral ... See more keywords
A randomised, multicentre trial of somatostatin to prevent clinically relevant postoperative pancreatic fistula in intermediate-risk patients after pancreaticoduodenectomy
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Gastroenterology"
DOI: 10.1007/s00535-021-01818-8
Abstract: Prophylactic somatostatin to reduce the incidence of clinically relevant postoperative pancreatic fistula after pancreaticoduodenectomy remains controversial. We assessed the preventive efficacy of somatostatin on clinically relevant postoperative pancreatic fistula in intermediate-risk patients who underwent pancreaticoduodenectomy… read more here.
Keywords: pancreatic fistula; postoperative pancreatic; clinically relevant; fistula ... See more keywords
Impact of breast cancer risk factors on clinically relevant prognostic biomarkers for primary breast cancer
Sign Up to like & getrecommendations! Published in 2021 at "Breast Cancer Research and Treatment"
DOI: 10.1007/s10549-021-06294-5
Abstract: In addition to impacting incidence, risk factors for breast cancer may also influence recurrence and survival from the disease. However, it is unclear how these factors affect combinatorial biomarkers for aiding treatment decision-making in breast… read more here.
Keywords: prognostic biomarkers; risk factors; breast cancer; clinically relevant ... See more keywords
Endotracheal catheter equipped with functional cuff produces clinically relevant positive end expiratory pressure: a bench study
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Monitoring and Computing"
DOI: 10.1007/s10877-018-0189-1
Abstract: Recently, we developed a novel endotracheal catheter with functional cuff (ECFC). Using such an ECFC and a regular ICU ventilator, we were able to generate clinically relevant tidal volume in a lung model and adult… read more here.
Keywords: catheter; tidal volume; peep cmh2o; ecfc ... See more keywords